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Role of ShcC adaptor protein in neuronal survival and differentiation

Objetivo

I will test if ShcC-driven signalling events in postmitotic neurons are critical for neuronal viability and phenotypic stability.

We will test this possibility by:
1) producing mice and derive cells in which mature neurons are deleted of ShcC in a constitutive or inducible manner
2) identifying promoter sequences and molicules important for ShcC expression in mature neurons
3) identifying the downstream signalling events initiated by ShcC in CNS neurons

Tema(s)

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Convocatoria de propuestas

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Coordinador

The University of Edinburgh
Aportación de la UE
Sin datos
Dirección
West mains road, king's buildings
EH9 3JQ Edinburgh
Reino Unido

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Coste total
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Participantes (1)