Obiettivo I will test if ShcC-driven signalling events in postmitotic neurons are critical for neuronal viability and phenotypic stability.We will test this possibility by:1) producing mice and derive cells in which mature neurons are deleted of ShcC in a constitutive or inducible manner2) identifying promoter sequences and molicules important for ShcC expression in mature neurons3) identifying the downstream signalling events initiated by ShcC in CNS neurons Campo scientifico natural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) Data not available Invito a presentare proposte Data not available Meccanismo di finanziamento RGI - Research grants (individual fellowships) Coordinatore The University of Edinburgh Contributo UE Nessun dato Indirizzo West mains road, king's buildings EH9 3JQ Edinburgh Regno Unito Mostra sulla mappa Costo totale Nessun dato Partecipanti (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto Not available Italia Contributo UE Nessun dato Indirizzo Mostra sulla mappa Costo totale Nessun dato