Objectif G4-DNA is a stable linear DNA molecule made of consecutive planes of 4 guanine (G) bases connected with 4 poly-G strands. The aim of this project is to produce a novel G4-DNA wire with and without metal ions in the internal cores of G tetraplexes. A linear arrangement of redox-active ions in the centre line of the molecule will lead to the formation of a molecular wire by means of electron transfer or transport. The ability to incorporate metal ions with different contributions to the conduction properties into a single G4-DNA wire will enable the construction of wires composed of segments with high and low resistance regions along the conductor. The electrical transport properties of single G4-DNA wires will be studied by scanning tunnelling microscopy and spectroscopy and the conductivity along single G4-DNA molecules will be monitored by direct electrical transport measurements between metal nano-electrodes. The development of such molecular wires and devices may lay a basis for DNA-based Nano-electronics.OBJECTIVESThe objective of this proposal is to develop G4-DNA-based nano-electronics. G4-DNA is a four-stranded structure that contains a planar arrangement of four guanine (G) nucleotides. We will produce conducting organic wires based on complexes of G4-DNA and also G4-DNA with metal-ions in the central space of each G4 plane. Electrical transport through single G4-DNA wires of different length and metal composition will be measured. Electronic conductivity of G4-DNA based wires will be altered by changing the nature of metal ions in the wire and the average distance between the neighbouring metal ions.DESCRIPTION OF WORKG4-DNA with and without different metal-ions will be prepared. The G4-DNA molecules will be deposited and attached to a metal surface. Scanning tunnelling microscopy and spectroscopy will be employed at temperatures ranging from room temperature down to cryogenic temperatures to study the electrical properties of single G4-DNA molecules. The electrical conductivity of these wires will be monitored by direct electrical transport measurements. Champ scientifique natural sciencesphysical scienceselectromagnetism and electronicsnatural sciencesbiological sciencesgeneticsDNAnatural sciencesphysical sciencesopticsmicroscopynatural sciencesbiological sciencesgeneticsnucleotidesnatural sciencesphysical sciencesopticsspectroscopy Mots‑clés Nanotechnology Programme(s) FP5-IST - Programme for research, technological development and demonstration on a "User-friendly information society, 1998-2002" Thème(s) 1.1.2.-6.1.1 - FET O: Open domain Appel à propositions Data not available Régime de financement ACM - Preparatory, accompanying and support measures Coordinateur TEL AVIV UNIVERSITY Contribution de l’UE Aucune donnée Adresse Ramat Aviv TEL AVIV Israël Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSIDAD DE VALLADOLID Espagne Contribution de l’UE Aucune donnée Adresse PLAZA SANTA CRUZ 8 47002 VALLADOLID Voir sur la carte Coût total Aucune donnée
