Objetivo The proposal describes how steps will be made to advance in the knowledge of is oprenoid biosynthesis in order to produce specific inhibitors that will be of use in the treatment of the leishamniases. Focus will be placed on the development of inhbitors against two enzymes: farnesyl diphosphate syntheses and squalling syntheses. Advantage will be taken of the existing knowledge on the inhibition of these enzymes in other organisms and of the crystal structures available for the modelling of the active site of the protozoan enzymes and identification of lead molecules. Alterations in is oprenoid composition, effects on parasite ultrustructural morphology and the intracellular localization of these enzymes will be studied in order to use the information in understanding drug toxicity, mode of action and intracellular transport requirements. Ámbito científico engineering and technologymaterials engineeringcrystalsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programa(s) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Tema(s) Data not available Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Aportación de la UE Sin datos Dirección Calle Ventanilla 11 18001 GRANADA España Ver en el mapa Coste total Sin datos Participantes (3) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo FEDERAL UNIVERSITY OF RIO DE JANEIRO Brasil Aportación de la UE Sin datos Dirección S/N,Edificio do Centro de Ciencias da Saude, Bloco G 21949-900 RIO DE JANEIRO Ver en el mapa Coste total Sin datos INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTIFICAS Venezuela Aportación de la UE Sin datos Dirección KM 11,Altos de Pipe, KM. 11, Carretera Panamericana 1020 CARACAS Ver en el mapa Coste total Sin datos UNIVERSITY OF WALES CARDIFF Reino Unido Aportación de la UE Sin datos Dirección King Edward VII Avenue, Redwood Building CF10 3XF CARDIFF Ver en el mapa Coste total Sin datos