Obiettivo Leishmaniasis is a severe health problem in DCs and Europe. Pentavalent antimonials (SbV)will remain the first line drug for the forthcoming years. Control is being challenged by increased SbV resistance. Our aim is to design molecular tools for detecting emergence and spreading of drug resistance in visceral and mucocutaneous leishmaniases. To achieve this, we will obtain samples from SbV susceptible and refractory patients (Nepal, Bolivia, Peru ), identify molecular modifications associated with SbV resistance in FIELD isolates, transfer this Knowledge into molecular tools for drug resistance diagnosis, and define the population structure of sensitive and resistant isolates for understanding the epidemiological dynamics of drug resistance. Outputs: collection of naturally resistant parasites, knowledge on natural mechanisms generating SbV resistance and its transmission, PCR tools for preventing therapeutic failure and guidelines for their use in epidemiological surveillance. Campo scientifico medical and health sciencesbasic medicinepharmacology and pharmacydrug resistance Programma(i) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Argomento(i) Data not available Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore INSTITUTE OF TROPICAL MEDICINE PRINCE LEOPOLD Contributo UE Nessun dato Indirizzo 155,Nationalestraat 155 2000 ANVERS /ANTWERPEN Belgio Mostra sulla mappa Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto B.P. KOIRALA INSTITUTE OF HEALTH SCIENCES Nepal Contributo UE Nessun dato Indirizzo Ramshah Road KATHMANDU Mostra sulla mappa Costo totale Nessun dato LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE Regno Unito Contributo UE Nessun dato Indirizzo Keppel Street LONDON Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSIDAD MAYOR DE SAN SIMON Bolivia Contributo UE Nessun dato Indirizzo Avenida Aniceto Arce 0371 COCHABAMBA Mostra sulla mappa Costo totale Nessun dato UNIVERSIDAD PERUANA CAYETANO HEREDIA Perú Contributo UE Nessun dato Indirizzo Avda Honorio Delgado s/n 100 LIMA Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF GENEVA Svizzera Contributo UE Nessun dato Indirizzo Rue Micheli-du-Crest 24 1211 GENEVE Mostra sulla mappa Costo totale Nessun dato
