Objective The recent apparition of BSE and cud in Europe has raised tremendously the public interest in "health and consumer protection" with regard to food and to other derived products susceptible to carrying the infectious agent of these diseases. This proposal will focus on the mechanisms of neurodegeneration in Tees and in particular on the relationship between Prep expression, metal ion metabolism and oxidative stress. The role of two additional pathogenic factors, a transmembraneform of Prep and Doppler, a Prep related protein, will also be considered. Experimental approaches will include cellular and animal models of Tees and state of the art techniques in oxidative stress and signal transudation analysis. We believe that advances in the knowledge of the Prep physiological and pathological function, as well as in the mechanisms of neurodegeneration in Tees will provide the basis to new preventive and/or therapeutic strategies against these diseases. Fields of science natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-9. - Neurosciences Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE EU contribution No data Address Rue de la cardonille 141 34396 Montpellier France See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE France EU contribution No data Address Domaine de vilvert 78352 Jouy-en-josas See on map Total cost No data MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH Italy EU contribution No data Address Via eritrea 62 20157 Milano See on map Total cost No data UNIVERSITE JOSEPH FOURIER - GRENOBLE 1 France EU contribution No data Address Domaine de la merci 38706 La tronche See on map Total cost No data UNIVERSITY OF HAMBURG Germany EU contribution No data Address 52,falkenried 94 20251 Hamburg See on map Total cost No data UNIVERSITY OF LEEDS United Kingdom EU contribution No data Address Woodhouse lane LS2 9JT Leeds - west yorkshire See on map Total cost No data