Objective The objective of this proposal is to obtain novel functional biocatalysts for region- and emanation-selective oxidation working in a 'reactor plugged to a wall socket'. A central part is the isolation of the responsible part of monooxygenases and the combination with an electrochemical regeneration system. Our aim is to use sophisticated mediator technology to develop biocatalysts, which, in an industrial setting, are competitive to chemical catalysis used in hydroxylation. Together with an integration of mechanistic information of the enzymes and genetic engineering techniques, a large number of mutants prepared by directed evolution will be analysed by novel massive parallel screening methods. Based on the developments a basically new electro-enzymatic reactor will be constructed for chemical bulk synthesis of oxygenated fine chemicals. Fields of science natural scienceschemical scienceselectrochemistryelectrolysismedical and health sciencesmedical biotechnologygenetic engineeringnatural scienceschemical sciencescatalysisbiocatalysisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator BASF AG EU contribution No data Address Carl-Bosch-Straße 38 67063 Ludwigshafen Germany See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all SWISS FEDERAL INSTITUTE OF TECHNOLOGY ZUERICH Switzerland EU contribution No data Address 101,ETH Hoenggerberg, HPT 8093 ZURICH See on map Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution No data Address South Parks Road OX1 3QR OXFORD See on map Total cost No data UNIVERSITAET STUTTGART Germany EU contribution No data Address Allmandring 31 Zentrum für Bioverfahrenstechnik 70569 Stuttgart See on map Total cost No data UNIVERSITE PAUL SABATIER DE TOULOUSE III France EU contribution No data Address Route de Narbonne 118 URA 192 31062 TOULOUSE See on map Total cost No data VRIJE UNIVERSITEIT AMSTERDAM - VERENIGING VOOR CHRISTELIJK WETENSCHAPPELIJK ONDERWIJS Netherlands EU contribution No data Address 1083,De Boelelaan 1083 1081 HV AMSTERDAM See on map Total cost No data