Objective Knowledge of the extent of linkage disequilibrium (LD) and its variation across the genome is required for the efficient and systematic implementation of mapping functional polymorphisms implicated in common, complex disorders.. The overall goal of this project is to determine extent and variation of LD in the genome of the general population of European populations. DNA from population samples of unrelated individuals will be typed with some 250 micro satellites and SNPs in nine genomic regions and the entire chromosome 22 (C22). The extent of LD will be measured for each region and for C22, and will be compared across populations. The across-population variability of extent of LD will be interpreted by the demographic history of each population. Each genome region will be compared for extent of LD across chromosomes and between populations. Inherent genome, sequence-related characteristics will be used to interpret regional variability. Regions harbouring genes implicated in complex disorders will also be studied. Frequencies phaplotypes extending across each genomic region will be estimated for each population. Computer programs used for data analysis and all DNA types generated in this project will be available to the public at the completion of this project. Fields of science natural sciencescomputer and information sciencesdata sciencenatural sciencesbiological sciencesgeneticsDNAengineering and technologymechanical engineeringvehicle engineeringaerospace engineeringsatellite technologynatural sciencesbiological sciencesgeneticschromosomesnatural sciencesbiological sciencesgeneticsgenomes Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-8. - Research into genomes and diseases of genetic origin Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator FONDATION JEAN DAUSSET - CENTRE D'ETUDE DU POLYMORPHISME HUMAIN EU contribution No data Address Rue Juliette Dodu 27 75010 PARIS France See on map Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all CANCER RESEARCH UK United Kingdom EU contribution No data Address John Radcliffe Hospital - Institute of Molecular M OX3 9DU OXFORD/HEADINGTON See on map Total cost No data CONSORTIUM NATIONAL DE RECHERCHE EN GÉNOMIQUE France EU contribution No data Address Rue Gaston Cremieux, 2 91057 EVRY See on map Total cost No data UNIVERSITA DEGLI STUDI DI PAVIA Italy EU contribution No data Address Via Ferrata 1 27100 PAVIA See on map Total cost No data UNIVERSITAT POMPEU FABRA Spain EU contribution No data Address C/ Dr. Aiguader 80 08003 BARCELONA See on map Total cost No data UNIVERSITY OF BERNE Switzerland EU contribution No data Address Baltzerstrasse 6 3012 BERN See on map Total cost No data UNIVERSITY OF HELSINKI Finland EU contribution No data Address Kytoesuontie 11 00014 HELSINKI See on map Total cost No data UNIVERSITY OF TORINO Italy EU contribution No data Address Via Santena 19 10126 TORINO (TURIN) See on map Total cost No data
