Objetivo Proposal aim is to identify novel targets for pharmacological treatment of alcoholism. In an integrative approach, complementary expertise of 5 laboratories is applied. Pharmacologically validated animal models are adapted for generation of tissue from key brain regions. RNA is purified, and gene expression profiles established using Affymetrix methodology. An expression database is constructed, and mining the database identifies candidate genes differentially expressed in the functional models. Candidates are prioritised on the basis of available knowledge and availability of pharmacological tools, and confirmed using real time PCR and in site hybridisation. Confirmed targets are fed back into the functional models, where pharmacological and molecular manipulations of targets are evaluated for their ability to block alcohol drinking and reinstatement. Validated targets are patented and provide seeds for drug development. Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencescomputer and information sciencesdatabasesnatural scienceschemical sciencesorganic chemistryalcoholsnatural sciencesbiological sciencesgeneticsRNA Programa(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Tema(s) 1.1.1.-9. - Neurosciences Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador KAROLINSKA INSTITUTE Aportación de la UE Sin datos Dirección Huddinge University Hospital 141 86 HUDDINGE Suecia Ver en el mapa Coste total Sin datos Participantes (4) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo CENTRAL INSTITUTE OF MENTAL HEALTH Alemania Aportación de la UE Sin datos Dirección J5 68159 MANNHEIM Ver en el mapa Coste total Sin datos FUNDACION HOSPITAL CARLOS HAYA España Aportación de la UE Sin datos Dirección Plazsa del Hosptial Civil, s/n Hosptial Civil. Pab 29010 ESTEPONA (MALAGA) Ver en el mapa Coste total Sin datos NATIONAL PUBLIC HEALTH INSTITUTE Finlandia Aportación de la UE Sin datos Dirección Tukholmankatu, 2 00251 HELSINKI Ver en el mapa Coste total Sin datos UNIVERSITÀ DEGLI STUDI DI CAMERINO Italia Aportación de la UE Sin datos Dirección Via Scalzino 3 62032 CAMERINO Ver en el mapa Coste total Sin datos
