Obiettivo An optimal immunotherapeutic regimen will be established and its efficacy evaluated in HIV-infected individuals. The proposal comprises the improvement of an adjuvant protein HIV vaccine for therapeutic use that has proved efficacious in a stringent rhesus monkey SHIV challenge rode. The irnprovement will be achieved through combination of the adjuvant protein vaccine with particle-mediated immune delivery of DNA in prime-boost immunization regimen. This regimen will be investigated in mice and rhesus monkeys for superior immunogenicity and efficacy. One or several prime-boost immunization regimen will be evaluated in initial phase I clinical trials in exonerative volunteers. If the prime-boost combinations are immunogenic, the best combination will be tested for its efficacy in a therapeutic trial in HIV-Positive patients. Campo scientifico medical and health sciencesbasic medicineimmunologyimmunisationnatural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-2. - Key action Control of Infectious Diseases Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore GLAXOSMITHKLINE BIOLOGICALS SA Contributo UE Nessun dato Indirizzo Rue de l'Institut 89 --- RIXENSART Belgio Mostra sulla mappa Costo totale Nessun dato Partecipanti (2) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE Paesi Bassi Contributo UE Nessun dato Indirizzo 157,Lange Kleiweg 139 2288 GJ RIJSWIJK ZH Mostra sulla mappa Costo totale Nessun dato SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL Svezia Contributo UE Nessun dato Indirizzo Nobels vaeg 18 SOLNA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato
