Objective
The main objective of the contract, the prototype of a highly selective heparin-absorbing filter (H.A.F.) has been achieved. This filter may allow the use of membrane dialysers with regional (i.e. confined to the extracorporeal region) heparinization, preventing the occurrence of serious side effects due to increased heparin levels in the patient's blood. It is composed of a reservoir (container) containing rigid beads coated with a biocompatible polysaccharide hydrogel layer, where are grafted macromolecular chains which selectively absorb heparin. The filter combines limited dimensions, its internal volume being about 50 ml, with high efficiency both in terms of heparin-absorbing capacity and heparin-absorbing rate. The bioactive component of the filter appears to be endowed with good hemocompatibility by all in vitro tests. A limited number of animal experiments confirmed the high heparin-absorbing efficiency of the filter, confirming the advisability of further investigations for tuning the device to the needs of the clinical use.
The proposed research is directed on developing a selective de-heparinizing filter for blood, to be used for de-heparinizing blood in patients receiving heparin as an anticoagulant agent to avoid thrombus formation, for instance in extracorporeal circuits.
The problems induced by heparin administration are especially felt by patients undergoing haemodialysis, for whom it represents one the cause of morbidity. It is anticipated that the filter will allow to confine heparin within the extracorporeal circuit by re-adsorbing it just before blood re-enters the patient's body, thus achieving regional heparinization. Previous research had shown that some synthetic hydrogels of poly(amidoamine) structure have very high capability and selectivity in adsorbing heparin from blood. These hydrogels will be grafted onto glass beads entirely coated with biocompatible polysaccharides, in order to join regular shape, optimal size, good mechanical properties and relatively high density.
The key points of the research are:
- Optimizing the filter's design, including development of a mathematical model;
- coating beads with polysaccharides;
- grafting poly(amido-amines) onto the polysaccharide-coated beads;
- studying the heparin-adsorbing properties and the biocompatibility of the beads both in vitro, ex vivo, and in vivo;
- preparing a filter prototype ready for clinical studies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering coating and films
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- medical and health sciences clinical medicine nephrology renal dialysis
- natural sciences mathematics applied mathematics mathematical model
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
25123 Brescia
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.