Objectif Anomalous dynamic behaviour of lipid membranes near the chain-ordering phase transition (main transition) is determined by the fact that they are quasi-two-dimensional systems in which the in-plain processes, being essentially two-dimensional, are nevertheless influenced by the out-of-plain motions. The mechanism of the transition is far from being fully understood. The signs of the first-order (discontinuity in the enthalpy and volume) and second-order transitions (anomalous fluctuations and swelling) are displayed simultaneously. Several approaches to the explanation of such a combination of properties are known. Those based on the idea of the weak-first-order character of the transition seem to be the most appropriate and attractive; this is the main direction of the theoretical consideration in this project. What is the transition mechanism? What is the relationship between the in-plain and out-of-plain properties of lipid membranes? In particular, how does the dynamic behaviour of lipid systems depend on the shape of the interlayer interactions? What is the lifetime of short-lived and long-lived heterogeneous patterns in the systems? How do these properties depend on the lipid structure and composition? This set of questions is what the project is devoted to.In case of successful implementation of the project, hopefully, the problem of the physical mechanism of main phase transition and the origin of the pre-transitional anomalies will be closed. The role of the in-plain density fluctuations in the interlayer interaction will be understood. The role of the anharmonicity of interaction potentials in the membrane dynamics will be clarified. One of the most attractive perspectives is presented by the parts devoted to the compound formation phenomenon in mixed systems and the cooperativity of phase transition. These properties might have a direct relation to a wide spectrum of general biological and medical problems - through an idea that the phase transition and the membrane dynamics are crucial for brain excitability. This fact determines practical biomedical benefits from the proposed physical study.This project is a multidisciplinary study that involves six research groups experienced in the theoretical and experimental studies of the structure, thermodynamics, kinetics, molecular interactions, and hydration in colloid systems and also in the biological aspects of the structure and dynamics of lipid membranes. The static and time-resolved X-ray diffractometry, molecular acoustics, calorimetry, densitometry, and atomic force microscopy are within the experimental methods used. Programme(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Thème(s) 1B - Condensed Matter, Optics and Plasma Physics OPEN - OPEN Call Appel à propositions Data not available Régime de financement Data not available Coordinateur Austrian Academy of Sciences Contribution de l’UE Aucune donnée Adresse Schmiedlstra?e 6 8042 Graz Autriche Voir sur la carte Coût total Aucune donnée Participants (5) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire Belarus National Academy of Sciences Biélorussie Contribution de l’UE Aucune donnée Adresse Staroborisovsky Trakt, 36 220141 Minsk Voir sur la carte Coût total Aucune donnée Institute Laue Langevin France Contribution de l’UE Aucune donnée Adresse 6 rue Jules Horowitz 38420 Grenoble Voir sur la carte Coût total Aucune donnée Lund University Suède Contribution de l’UE Aucune donnée Adresse Getingevagen 60 22100 Lund Voir sur la carte Coût total Aucune donnée Russian Academy of Sciences Russie Contribution de l’UE Aucune donnée Adresse Institutskaya 3 142290 Pushchino, Moscow Region Voir sur la carte Coût total Aucune donnée Russian Academy of Sciences Russie Contribution de l’UE Aucune donnée Adresse Leninsky Prospect 59 117333 Moscow Voir sur la carte Coût total Aucune donnée
