Objectif The main objective is to create, to investigate and to describe mathematically a new system for unconjugated bilirubin (UB) removal from human serum albumin (HSA) containing solutions. To achieve this objective a new type of highly activated synthetic carbons (carbonic pyropolymers, CPP) will be designed and optimised for bilirubin removal. Physicochemical properties and adsorptive capacity of novel CPP to extract a wide spectrum of bioactive substances will be studied and new experimental and mathematical models of unconjugated bilirubin removal from albumin containing media will be developed.The main steps of the research program are:- Synthesis: synthesis of CPP on the base of porous vinylpyridine-styrene-divinylbenzene copolymer and phenol-formaldehyde resins and their surface modification;- Characterization of properties and mechanism of action: investigation of physicochemical properties of CPP and mechanisms of UB removal in the presence of HSA;- Bioadsorption experiments: study of adsorption capacity of CPP towards creatinine, uric acid, free fatty acids, cholic acids, phenols, proinflammatory cytokines, and other low-, middle- and high molecular mass metabolites;- Experimental modelling: development of experimental models for bilirubin removal and their in vitro testing;- Mathematical modelling: mathematical description of UB adsorption onto CPP in the presence of HSA and numerical computation of UB extraction in double-compartment model with excitations.The most important scientific results expected from this project are:1. A new type of carbonic adsorbents;2. Novel preparative procedures to optimise CPP properties for UB adsorption from HSA containing media;3. Physicochemical characterisation of newly designed CPP with adsorptive activity towards selected biologically active substances superior to alternative adsorbents;4. Determination of physicochemical mechanisms of UB adsorption onto CPP in the presence of HSA;5. Non-linear numerical model of UB removal with predictive capability for real clinical situations where "artificial liver" supporting systems are applicable.By achieving the aims and objectives of this project a major breakthrough on the way to designing an artificial liver and liver supporting systems will be made. Programme(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Thème(s) 4 - Life Sciences OPEN - OPEN Call Appel à propositions Data not available Régime de financement Data not available Coordinateur King's College, University of London Contribution de l’UE Aucune donnée Adresse Bessemer Road SE5 9PJ London Royaume-Uni Voir sur la carte Coût total Aucune donnée Participants (5) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire Danube University of Krems Autriche Contribution de l’UE Aucune donnée Adresse Dr Karl Dorrek Strasse 30 3500 Krems Voir sur la carte Coût total Aucune donnée Ministry of Health Russie Contribution de l’UE Aucune donnée Adresse Malaya Pyrogovskaya St 1-A 119828 Moscow Voir sur la carte Coût total Aucune donnée National Academy of Sciences of Ukraine Ukraine Contribution de l’UE Aucune donnée Adresse Vasilkovskaya Str, 45 03022 Kiev Voir sur la carte Coût total Aucune donnée State University Russie Contribution de l’UE Aucune donnée Adresse Institutskii Proezd 9 141700 Dolgoprudnyi, Moscow Region Voir sur la carte Coût total Aucune donnée University of Brighton Royaume-Uni Contribution de l’UE Aucune donnée Adresse Lewes Road BN2 4GJ Brighton Voir sur la carte Coût total Aucune donnée
