Objectif The process of demyelination accompanies many neurological diseases. The intensity of demyelination and induction of inflammation depends on the adhesive ability of myelin basic protein (MBP) to oligodendrocytes and T-lymphocytes. The proposed project is aimed at studying the influence of various types of post-translational modifications (phosphorylation, amination, ADP-ribosylation) on the adhesive properties of MBP. The project is directed towards the following points:(i) purification and preparation of various modified (phosphorylated, ADP-ribosylated, deaminated) forms of MBP;(ii) Study of kinetics of adhesion of different modificated isoforms of MBP with artificial membranes and with lymphocytes from normal and multiple sclerosis (MS) patients;(iii) Investigation of secretion of cytokines from lymphocytes of healthy and MS patients under the action of the various isoforms of MBP. Results will hopefully reveal the functionally active form of MBP, which participates in the process of myelin repair, and also the immunogenic form of MBP, which causes restriction of T-lymphocytes. Programme(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Thème(s) 4 - Life Sciences GEORGIA - GEORGIA Appel à propositions Data not available Régime de financement Data not available Coordinateur Basel Univesity Contribution de l’UE Aucune donnée Adresse Spitalstrasse, 51 4056 Basel Suisse Voir sur la carte Coût total Aucune donnée Participants (2) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire Georgian Academy of Sciences Géorgie Contribution de l’UE Aucune donnée Adresse Gothua str. 380060 Tbilisi Voir sur la carte Coût total Aucune donnée National Council of Research Italie Contribution de l’UE Aucune donnée Adresse Via Tommaso Pendola 62 53100 Siena Voir sur la carte Coût total Aucune donnée
