Objetivo Clinical data from radiotherapy and experimental evidence obtained in vitro demonstrate the existence of inter-individual variation in response to ionising irradiation. The contribution of age, genetic polymorphism and environmental factors to these variations is still unknown. We propose to identify cellular phenotypes, related to individual radiosensitivity. This will permit the identification of involved functional and positional candidate genes, whose polymorphisms actually modulate individual radiosensitivity. The proposed approach is based on the exploitation of the unique GENEPI biological resource, the use of two recently validated, quantitative in vitro assays of radiosensitivity, and on the application of state-of-the-art gene expression profiling technology. Results of the study are intended to lead to the development of a predictive test for individual radiosensitivity, capable of identifying persons at risk. Ámbito científico natural sciencesbiological sciencesgenetics Programa(s) FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002) Tema(s) 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador FONDATION JEAN DAUSSET - CENTRE D'ETUDE DU POLYMORPHISME HUMAIN Aportación de la UE Sin datos Dirección Rue Juliette Dodu 27 75010 PARIS Francia Ver en el mapa Coste total Sin datos Participantes (2) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo BELGIAN NUCLEAR RESEARCH CENTRE Bélgica Aportación de la UE Sin datos Dirección Boeretang 200 2400 MOL Ver en el mapa Coste total Sin datos COMMISSARIAT A L'ENERGIE ATOMIQUE Francia Aportación de la UE Sin datos Dirección Avenue du General Leclerc 60-68 92265 FONTENAY AUX ROSES Ver en el mapa Coste total Sin datos
