Obiettivo The clearance of dying cells is the last phase of apoptosis in vivo. Corpse removal prevents inflammation and autoimmunity. We plan to develop therapeutic strategies aimed to restore in vivo clearance, in order to prevent tissue damage and chronic inflammation. To this aim we will characterise the molecular machinery involved, using complementary approaches (from genetic screening in C. elegans to function complementation in autoimmune patient phagocytes). We will establish a panel of clearance defective animals bearing combined modifications of relevant genes and study the consequences of accumulation of apoptotic cells in selected tissues on the homeostasis of the organism. We will characterise the effect of molecular interventions in vivo in models of acute and chronic tissue inflammation. Finally we will exploit this system to identify novel autoantigens in vivo, which will be validated as diagnostic tools in patients with systemic autoimmune diseases. Campo scientifico medical and health sciencesbasic medicineimmunologyautoimmune diseasesmedical and health sciencesbasic medicinephysiologyhomeostasis Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-3. - Key action The "Cell factory" Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR - ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO Contributo UE Nessun dato Indirizzo Via Olgettina 58 20132 MILANO Italia Mostra sulla mappa Costo totale Nessun dato Partecipanti (8) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto DIESSE DIAGNOSTICA SENESE SPA Italia Contributo UE Nessun dato Indirizzo Via S. Vittore 36/1 20100 MILANO Mostra sulla mappa Costo totale Nessun dato GENERA SPA Italia Contributo UE Nessun dato Indirizzo Via Olgettina 58 20132 MILANO Mostra sulla mappa Costo totale Nessun dato INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francia Contributo UE Nessun dato Indirizzo Parc Scientifique de Luminy 13288 MARSEILLE Mostra sulla mappa Costo totale Nessun dato INSTITUTE FOR INFECTIOUS DISEASES "LAZZARO SPALLANZANI" Italia Contributo UE Nessun dato Indirizzo Via Portuense, 292 00149 ROMA Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF DEBRECEN Ungheria Contributo UE Nessun dato Indirizzo Egyetem tér. 1 DEBRECEN Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF ERLANGEN-NUREMBERG Germania Contributo UE Nessun dato Indirizzo Egerlandstrasse 1 91058 ERLANGEN Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF ZURICH Svizzera Contributo UE Nessun dato Indirizzo 71,Raemistrasse 71 CH-8091 ZURICH Mostra sulla mappa Costo totale Nessun dato University of Edinburgh Regno Unito Contributo UE Nessun dato Indirizzo Old College South Bridge EH1 1HN Edinburgh Mostra sulla mappa Costo totale Nessun dato
