Objective This programme will demonstrate that the transfer of specific genes from an Aspergillums Niger strain, which produces citric acid with close to theoretical efficiency, into other commercial micro-organisms will enhance the pool of precursors in those organisms and lead to increased yield and production rates for their end products. The two key enzymes, pike and axle, lead to increased glycol tic flux and the uncoupling of respiration from ATP production respectively, which, together with high glucose levels, will lead to increased metabolic fluxes and steady state levels of intermediates. Such a demonstration of high yield and productivity will then be transferred directly to the production strains of European manufacturers. Fields of science social scienceseconomics and businesseconomicsproduction economicsproductivitynatural sciencesbiological sciencesmicrobiologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme DEM - Demonstration contracts Coordinator NATIONAL INSTITUTE OF CHEMISTRY EU contribution No data Address 19,Hajdrihova 19 1150 LJUBLJANA Slovenia See on map Links Website Opens in new window Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all ARISTOTLE UNIVERSITY OF THESSALONIKI Greece EU contribution No data Address University Campus, Egnatia Street, Administration 54006 THESSALONIKI See on map Total cost No data BEOCARTA LTD United Kingdom EU contribution No data Address Colville Building, North Portland Street 48 G1 1XN GLASGOW See on map Total cost No data GRAZ, UNIVERSITY OF TECHNOLOGY Austria EU contribution No data Address RECHBAUERSTRASSE 12 8010 GRAZ See on map Total cost No data LEK, PHARMACEUTICAL AND CHEMICAL COMPANY D.D. Slovenia EU contribution No data Address Verovskova 57 1000 LJUBLJANA See on map Links Website Opens in new window Total cost No data UNIVERSITY OF STRATHCLYDE United Kingdom EU contribution No data Address 16 Richmond Street GLASGOW See on map Links Website Opens in new window Total cost No data
