Objective HIV-l vaccines are urgently needed especially in developing nations. HIV vaccine study sites are needed in developing nations for more rapid development and deployment of vaccines. DNA plasmid vaccines are promising candidates - Their potency needs to be improved. The programme will explore various modes of increasing the immunogenicity of priming with plasmid DNA; intradermal injections, with GM-CSF as adjuvant, intramucosal injections and boosting with a Modified Vaccinia Ankara vector, MVA. Vaccines produced from subtypes appropriate for Tanzania will be used. A study site will be established in Dar es Salaam- The prerequisites for approval will be addressed on all levels, paving the way to future trials - Immunogenicity studies will continue in Dar es Salaam, with a focus on mucosal immunity and durability of the immune response. Fields of science natural sciencesbiological sciencesgeneticsDNAmedical and health sciencesbasic medicineimmunologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Topic(s) 1.2.1.-1.4. - Research for development Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator KAROLINSKA INSTITUTE EU contribution No data Address Ringwaegen, 52 11883 STOCKHOLM Sweden See on map Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH Germany EU contribution No data Address 5,Leopoldstrasse 5 80802 MUENCHEN See on map Total cost No data MUHIMBILI UNIVERSITY COLLEGE OF HEALTH SCIENCES Tanzania EU contribution No data Address Off United Nations Road, West Upanga DAR ES SALAAM See on map Total cost No data STOCKHOLM SOEDER HOSPITAL Sweden EU contribution No data Address Ringvaegen, 52 11883 STOCKHOLM See on map Total cost No data UNIVERSITY OF CAPE TOWN South Africa EU contribution No data Address Anzio Road 7925 OBSERVATORY, CAPE TOWN See on map Total cost No data
