Objective Protein phosphorylation is a control mechanism that regulates most aspects of cell life. About one third of mammalian proteins contain covalently bound phosphate, and it now seems likely that protein kinases, protein phosphatases and their regulatory subunits will comprise several percent of all human gene products. Abnormal protein phosphorylation is a cause or consequence of major diseases, such as arthritis, Morbus Alzheimer, cancer, diabetes, hypertension and stroke, while defects in genes that encode particular protein kinases and phosphatases underlie a number of inherited disorders, including a variety of leukaemias, lymphomas and severe combined immunodeficiency syndromes. Here we focus on three different systems of sequentially regulated protein kinases designated as "protein kinase cascades" or "signalling cascades", which are involved in the development of cancer (the mitogen- activated protein kinase cascade - p42/44MAPK cascade), in inflammation (the p38 MAPK- or stress- activated protein kinase - SAPK - cascade) and in insulin signaling (the phosphoinositol-3 kinase/protein kinase B/Glycogen synthase kinase 3 - PI-3K/PKB/GSK3 - pathway). These signaling cascades contain different protein kinases as potential targets for therapeutic approaches. The aim of the proposal is to elucidate the role of the different protein kinases, to understand their molecular mechanisms of regulation and to identify their targets which are responsible for the specific effects by using genetic, biochemical and chemical approaches in combination. As a result, therapeutic targets for the treatment of cancer, inflammatory diseases as well as diabetes will be defined and the suitability of these targets will be analyzed in cell-based assays and model organisms. Fields of science medical and health sciencesbasic medicineneurologydementiaalzheimermedical and health scienceshealth sciencesinflammatory diseasesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesclinical medicineoncologyleukemia Programme(s) FP5-HUMAN POTENTIAL - Programme for research, technological development and demonstration on "Improving the human research potential and the socio-economic knowledge base" (1998-2002) Topic(s) Data not available Call for proposal Data not available Funding Scheme NET - Research network contracts Coordinator HANNOVER MEDICAL SCHOOL EU contribution No data Address Carl-Neuberg-Strasse 1, OE 4310, Gebaeude I3, Eben 30625 HANNOVER Germany See on map Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all BIOMEDICAL SCIENCES RESEARCH CENTRE "ALEXANDER FLEMING" Greece EU contribution No data Address Fleming Street 14-16 16672 GLYFADA (ATTIKI) See on map Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address Centre Antoine Lacassagne, 33 Av. Valombrose 06108 NICE See on map Total cost No data IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE United Kingdom EU contribution No data Address ARC Building, Aspenlea Road 1, Hammersmith W6 8LH LONDON See on map Total cost No data THE UNIVERSITY OF TUEBINGEN Germany EU contribution No data Address Auf der Morgenstelle, 15 72076 TUEBINGEN See on map Total cost No data UNIVERSITE DE NICE - SOPHIA ANTIPOLIS France EU contribution No data Address Centre Antoine Lacassagne, 33 Av. Valombrose 06189 NICE See on map Total cost No data UNIVERSITY MEDICAL CENTRE UTRECHT Netherlands EU contribution No data Address Universiteitsweg 100 3508 AB UTRECHT See on map Total cost No data UNIVERSITY OF DUNDEE United Kingdom EU contribution No data Address Nethergate DD1 4HN DUNDEE See on map Total cost No data UNIVERSITY OF ZURICH Switzerland EU contribution No data Address 190,Winterthurstrasse 190 8057 ZURICH See on map Total cost No data
