Cel After completion of yeast, Arabidopsis, Caenorhabditis, Drosophila and human genome sequences, the next challenging task of biology is to identify the functions of eukaryotic genes and their protein products, which is a prerequisite for future biotechnological applications. Building upon its traditional agricultural links, plant research can now deploy new research tools to functionally characterise the Arabidopsis and rice genomes using proteomics and functional genomics. As the function of genes is ultimately controlled by the stability of their protein products, a central target is to understand how the ubiquitination-dependent proteolysis pathways regulate the stability of proteins. In these pathways, E3 ubiquitin ligases SCF (Skp1-cullin-F-box protein) and APC/C (anaphase promoting complex) are essential to control the stability of regulatory factors involved in signal transduction, transcription and cell division. Due to applications in cancer biology, the study SCF and APC/C is a focus of intense current research. In Arabidopsis, about 2.5% of all proteins represent SCF and APC/C components suggesting that SCF and APC/C mediated proteolysis represents also a central regulatory pathway in plants. The goal of this proposal is to gain a generally applicable information about the function and regulation of conserved components of plant SCF and APC/C complexes. To reach this goal, a network will unite interdisciplinary expertise to study the composition and substrates of SCF and APC/C complexes using protein interaction, biochemical, mass spectrometry, physical and immunological techniques, reverse genetics, transcript profiling and high-through-put genetic engineering. The project aims to reach a break-through in our understanding of the role played by plant SCF and APC/C complexes in the regulation of cell division and signalling. Dziedzina nauki natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesclinical medicineoncologynatural scienceschemical sciencesanalytical chemistrymass spectrometrynatural sciencesbiological sciencesgeneticsgenomes Program(-y) FP5-HUMAN POTENTIAL - Programme for research, technological development and demonstration on "Improving the human research potential and the socio-economic knowledge base" (1998-2002) Temat(-y) 1.4.1.-1.1. - Research Training Networks Zaproszenie do składania wniosków Data not available System finansowania NET - Research network contracts Koordynator CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Wkład UE Brak danych Adres Rue de Général Zimmer 12 67084 STRASBOURG Francja Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (5) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko ALBERT-LUDWIGS-UNIVERSITAET FREIBURG Niemcy Wkład UE Brak danych Adres 1,Schaenzlestrasse 1 79104 FREIBURG (IN BREISGAU) Zobacz na mapie Koszt całkowity Brak danych CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francja Wkład UE Brak danych Adres Avenue de la Terrasse 1Bètiment 23 91190 GIF SUR YVETTE Zobacz na mapie Koszt całkowity Brak danych MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Niemcy Wkład UE Brak danych Adres Carl-von-Linné-Weg 10 50829 KOELN Zobacz na mapie Koszt całkowity Brak danych ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE Zjednoczone Królestwo Wkład UE Brak danych Adres Egham Hill TW20 0EX EGHAM,SURREY Zobacz na mapie Koszt całkowity Brak danych UTRECHT UNIVERSITY Niderlandy Wkład UE Brak danych Adres Padualaan 8 3584 CH UTRECHT Zobacz na mapie Koszt całkowity Brak danych
