Objetivo The objective of the present project is to decipher basic cellular and molecular processes that underlie disturbances in the control of biological rhythms withageing. The suprachiasmatic nucleus (SCN) plays a role of biological clock and is unique for studies of ageing phenomena at the cellular and molecular level that can be correlated to a distinct function, the regulation of biological rhythms, which undergoes major changes with ageing to deteriorate the quality of life. Despite the clinical evidence that biological rhythms are disrupted in elderly people, little is known about the molecular, cellular and functional changes occurring in the SCN with ageing. In the proposed project we will study changes of factors intrinsic to the neurons in the SCN as well as extrinsic factors in humans and experimental systems. The latter includes effects on the SCN by cytokines that increase in the blood and the brain in awed individuals. Programa(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Tema(s) 1.1.1.-6. - Key action The Ageing Population and Disabilities Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador KAROLINSKA INSTITUTE Aportación de la UE Sin datos Dirección Retzius Vaeg 8 171 77 STOCKHOLM Suecia Ver en el mapa Coste total Sin datos Participantes (3) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francia Aportación de la UE Sin datos Dirección Avenue du Petit Chateau 4 91800 BRUNOY Ver en el mapa Coste total Sin datos INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francia Aportación de la UE Sin datos Dirección 18,Avenue du Doyen Lepine 18 69675 BRON Ver en el mapa Coste total Sin datos UNIVERSITA DEGLI STUDI DI VERONA Italia Aportación de la UE Sin datos Dirección Strada Le Grazie, 8 37134 VERONA Ver en el mapa Coste total Sin datos
