Objetivo The DNA Damage Response (DDR) protects the genome from cytotoxic and mutagenic effects of chemicals and radiation in the environment. Genetic defects in DDR lead to genome instability and predispose individuals to diseases like cancer. DDR is a rapid, dynamic and integrated response to genome insult which co- ordinates cell cycle progression, DNA replication and DNA repair. Our understanding of DDR has been based largely on the use of specific approaches in specific model organisms: e.g. genetics in yeast, biochemistry in frogs, cytology in mammalian cells, etc. The participating teams are experts with these model organisms who are committed to expanding their repertoire of technical and conceptual approaches to studying DDR. Our objectives are:- To characterize mechanisms of genome surveillance in response to DNA damage and DNA replication stress by studying several key components (PI(3)- related kinases and associated subunits, Sgs1 helicasef PCNA and RF-C-related DDR components).- To examine the role of novel Components of the DNA damage signal transduction pathway.- To characterize the downstream effects of DDR on DNA replication, chromatin structure and ubiquit in mediated proteolysis. In each case, a multidisciplinary approach will involve the study of processes and proteins in different organisms using different technical strategies. This unique European collaboration will lead to new advances and contribute to an integrated view of DDR in eukaryotic cells. Ámbito científico natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicinephysiologycytologynatural sciencesbiological sciencesgeneticsgenomes Programa(s) FP5-HUMAN POTENTIAL - Programme for research, technological development and demonstration on "Improving the human research potential and the socio-economic knowledge base" (1998-2002) Tema(s) 1.4.1.-1.1. - Research Training Networks Convocatoria de propuestas Data not available Régimen de financiación NET - Research network contracts Coordinador CANCER RESEARCH UK Aportación de la UE Sin datos Dirección Clare Hall Laboratories, Blanche Lane EN6 3LD POTTERS BAR Reino Unido Ver en el mapa Coste total Sin datos Participantes (7) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo BEN GURION UNIVERSITY OF THE NEGEV Israel Aportación de la UE Sin datos Dirección 84105 BEER SHEVA Ver en el mapa Coste total Sin datos CANCER RESEARCH UK Reino Unido Aportación de la UE Sin datos Dirección Blanche Lane, Clare hall Laboratories EN6 3LD SOUTH MIMMS Ver en el mapa Coste total Sin datos ERASMUS UNIVERSITEIT ROTTERDAM Países Bajos Aportación de la UE Sin datos Dirección Dr. Molewaterplein 50 3000 DR ROTTERDAM Ver en el mapa Coste total Sin datos INSTITUT CURIE Francia Aportación de la UE Sin datos Dirección Rue d' Ulm 26 75248 PARIS Ver en el mapa Coste total Sin datos UNIVERSITY OF GENEVA Suiza Aportación de la UE Sin datos Dirección 30,Quai Ernest Ausermet 30 1211 GENEVE Ver en el mapa Coste total Sin datos UNIVERSITY OF SUSSEX Reino Unido Aportación de la UE Sin datos Dirección Falmer BN1 9RR BRIGHTON / FALMER Ver en el mapa Coste total Sin datos UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA Italia Aportación de la UE Sin datos Dirección Piazza della Scienza 2 20126 MILANO Ver en el mapa Coste total Sin datos