Cel Multipotent neural progenitor cells have an unlimited capacity for self-renewal and can differentiate into various cell types. They may constitute a source of donor tissue for cell replacement therapies in neurological disorders. Embryonic progenitors can be expanded and differentiated in vitro, but survival after transplantation is poor. We aim to increase the proliferation rate, dopaminergic. Differentiation and survival of rat, and subsequently human, midbrain progenitors in vitro and after transplantation in vivo. This will be achieved by treatment with a capsize inhibitor and a lipid per oxidation inhibitor at different time points in vitro and during the transplantation procedure. Cells will be transplanted into a rat Parkinson model and analysed functionally and immunohistochemically. Recent findings indicate that pluripotent stem cells also reside in the adult brain. There is evidence from a Swedish group that adult epidermal stem cells repopulate the substantial Ingra, but these cells need to be further characterised in vivo. Adult rodent epidermal stem cells will be analysed after transplantation with respect to their migratory behaviour and differentiation potential (egg transmitter phenotype and detailed morphology) to assess their possible use for neural grafting. Increased knowledge about neural stem cells should help turn neural grafting from a highly experimental procedure into a clinically useful treatment for a large number of patients with intractable neurological disorders. Dziedzina nauki natural scienceschemical scienceselectrochemistryelectrolysisnatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicineneurologyparkinsonmedical and health sciencesclinical medicinetransplantation Program(-y) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Temat(-y) 1.1.1.-6. - Key action The Ageing Population and Disabilities Zaproszenie do składania wniosków Data not available System finansowania RGI - Research grants (individual fellowships) Koordynator N/A Wkład UE Brak danych Adres Zobacz na mapie Koszt całkowity Brak danych
