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Identification of specific interactions between the transcription factor e2f-6 and polycomb group proteins, and the role of distinct complex formation in transcriptional repression.

Ziel

To identify specific E2F-6/Epc- 1L containing complexes by co-immunoprecipitation experiments in vitro and in vivo, and by purification of complexes through both affinity and gel filtration columns, and to characterise the role and biological importance of specific complexes in transcriptional repression.

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ISTITUTO EUROPEO DI ONCOLOGIA SRL
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