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Specificity, polymorphism and regulation of the toll-like receptor (tlr)-based innate host defense signal transduction system

Ziel

Toll-like receptors (TLR) sense the microbial presence. Tars promote expression of genes encoding ant microbial compounds via activation of the NF-cob signalling cascade. The aim is to resolve the specificity, polymorphism and regulation of the TLR4 and TLR2 signalling transudation system.

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