Cel In the thalamus, sensory inputs are integrated with state-dependent factors presumably via corticothalamic feedback. It is our aim to investigate the cellular and network mechanisms of this information processing. We have developed two complementary experimental strategies:1) Using thalamic networks in vitro that preserve in vivo-like oscillations, we will combine intracellular recordings with computer-controlled stimulation of cortical and sensory afferent fibbers.2) Introducing "hybrid" microcircuits, real thalamic neurons recorded in vitro will be connected with programmable neuromimetic model cells. This approach allows us to explore individual membrane currents of the biological and simulated thalamic cells and the properties of their synaptic, connections throughout their full dynamic range. We will examine the following working hypothesis:1) thalamic reticular interferon's filter sensory information flow by dynamic inhibition of thalamocortical relay neurons;2) this intrathalamic feedback inhibition is controlled by corticothalamic feedback through variable synaptic impacts on the different thalamic cell types;3) as mechanisms for the dynamic control of synaptic strength we postulate Spike-Timing Dependent Plasticity and the temporal structure of corticothalamic input. Our prediction is that a "variable gain control" of sensory information transfer by intrathalamic inhibition is imposed by a dynamic and plastic action of corticothalamic inputs.The expected impact for the applicant will be,1) transition from the study of individual neurone membrane conductance's towards integrative approaches to study neuronal networks, and2) participation in the development of new hybrid techniques for experimental exploration. Dziedzina nauki natural sciencescomputer and information sciencesdata sciencedata processing Program(-y) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Temat(-y) 1.1.1.-6. - Key action The Ageing Population and Disabilities Zaproszenie do składania wniosków Data not available System finansowania RGI - Research grants (individual fellowships) Koordynator CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Wkład UE Brak danych Adres Avenue de la Terrasse 1, Bètiment 32/33, Salle 352 91190 GIF SUR YVETTE Francja Zobacz na mapie Koszt całkowity Brak danych
