Obiettivo Apoptosis is a fundamental process in the development and homeostasis of multicultural organisms. Deregulation of apoptosis, however, can result in disease pathogenesis. Examples are cancer; autoimmune disease, neurodegenerative disease and organ transplant dysfunction. The concept of apoptosis modulation allows for novel therapeutics. Our proposal exploits molecular evolution and computational techniques to design novel therapeutic protein/ peptides molecules that modulate apoptosis signalling pathways at the TNF receptor-receptor family interface. Agonists or antagonists that interact at this interface will be mutants of native proteins, such as TRAIL. Alternatively, minimised de novo binding proteins will contain receptor or receptor binding domains fused to, or incorporated onto a stable turmeric scaffold. We expect to develop a general strategy for rapid design and construction of algometric proteins/peptides therapeutics Campo scientifico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineimmunologyautoimmune diseasesmedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesmolecular biologymolecular evolutionmedical and health sciencesbasic medicinephysiologyhomeostasis Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-3. - Key action The "Cell factory" Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITY OF GRONINGEN Contributo UE Nessun dato Indirizzo Anthony Deusinglaan 1 9700 AD GRONINGEN Paesi Bassi Mostra sulla mappa Costo totale Nessun dato Partecipanti (3) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto EUROPEAN MOLECULAR BIOLOGY LABORATORY Germania Contributo UE Nessun dato Indirizzo Meyerhofstrasse 1 HEIDELBERG Mostra sulla mappa Costo totale Nessun dato IQ CORPORATION BV Paesi Bassi Contributo UE Nessun dato Indirizzo Zernikepark 6E 9747 AN GRONINGEN Mostra sulla mappa Costo totale Nessun dato NATIONAL UNIVERSITY OF IRELAND, GALWAY Irlanda Contributo UE Nessun dato Indirizzo University Road 90 GALWAY Mostra sulla mappa Costo totale Nessun dato
