Obiettivo Lyme Borreliosis is the most common tick-borne infection in Eurasia, large parts of China, Japan, and North America. The disease manifests itself as a multi-system disorder, which can affect a complex range of tissues including the skin, musculoskeletal system, heart, and nervous system, leading to arthritis, carditis, and neuroborreliosis. The availability of the complete genome sequence from Borrelia burgdorferi has enabled the search for antigens and vaccine candidates among the complete proteome of this pathogen. This knowledge together with the use of human serum antibodies and whole-genome libraries will be applied to identify the most promising vaccine candidates from Borrelia in a very short time and without the need of expressing a large number of recombinant proteins. Applying the powerful combination of state-of-the-art experimental technologies and bioinformatics, we propose to identify common antigens from Borrelia burgdorferi, gannii and afzeiii, which can function as targets for protective immunity preventing LB and as markers for serodiagnosis. The participating SMEs and RTDs maintain the highest quality of research and technology in their respective field, among them proven and renowned experts of LB and Borrelia. The anticipated results of this project will be of immediate benefit to the involved SMEs. Novel diagnostic markers can be exploited commercially leading to a new standard in clinical diagnosis, whereas a prophylactic vaccine can enter clinical testing after completion of this project. Further benefits include the development of marketable research tools, the creation of international networks and the publication of results in scientific journals. This work will add to the repertoire of intellectual property of the involved SMEs and further broaden the expertise of both, RTDs and SMEs. At last, the project will be of great societal benefit by its contribution to the understanding of the underlying mechanisms of disease caused by Borrelia. Campo scientifico natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesclinical medicinerheumatologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesbasic medicinetoxicology Programma(i) FP6-SME - Horizontal research activities involving SMEs: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) SME-1 - Co-operative Research (all areas of science and technology) Invito a presentare proposte Data not available Meccanismo di finanziamento Data not available Coordinatore INTERCELL AG Contributo UE Nessun dato Indirizzo Campus Vienna Biocenter 6 VIENNA Austria Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto BIO TEST S.R.O. Cechia Contributo UE Nessun dato Indirizzo Pod Zamkem 279 KONAROVICE Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato MEDICAL UNIVERSITY VIENNA Austria Contributo UE Nessun dato Indirizzo Spitalgasse 23 VIENNA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato MWG BIOTECH AG Germania Contributo UE Nessun dato Indirizzo Anzinger Strasse 7a EBERSBERG Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato NATIONAL INSTITUTE OF PUBLIC HEALTH Cechia Contributo UE Nessun dato Indirizzo Srobarova 48 PRAGUE 10 Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UMEA UNIVERSITY Svezia Contributo UE Nessun dato Indirizzo Umea University UMEA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato
