Obiettivo The project aim is to provide new toxicological and epidemiological data to improve the risk assessment of dioxin and other food-derived endocrine disrupting chemicals (EDC). Focus is to clarify mechanisms behind functional diseases (osteoporosis) and structural malformations induced by EDCs through interactions with components of the nuclear receptor signalling pathways and other cell regulatory systems. We will address the hormonal cross-talk between Ah receptor (dioxin), retinoid as well as steroid hormone (estrogen) signalling pathways. Objectives will be achieved through the use of genetically modified animal models, gene array technology, proteomic and bioinformatic analysis, as well as traditional biomedical methods, and epidemiological studies. Obtained results will be used for(i) test method and biomarker development and for(ii) risk assessment purposes. Campo scientifico medical and health sciencesbasic medicinetoxicology Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-4. - Key action Environment and Health Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore KAROLINSKA INSTITUTE Contributo UE Nessun dato Indirizzo Nobels Vaeg, 13 171 77 STOCKHOLM Svezia Mostra sulla mappa Costo totale Nessun dato Partecipanti (8) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francia Contributo UE Nessun dato Indirizzo Rue Michel Ange 3 75794 PARIS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato GOETEBORG UNIVERSITY Svezia Contributo UE Nessun dato Indirizzo Vasaparken 405 30 GOETEBORG Mostra sulla mappa Costo totale Nessun dato INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francia Contributo UE Nessun dato Indirizzo Rue de Tolbiac, 101 75654 PARIS Mostra sulla mappa Costo totale Nessun dato MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH Italia Contributo UE Nessun dato Indirizzo Via Eritrea 62 20157 MILANO Mostra sulla mappa Costo totale Nessun dato NATIONAL PUBLIC HEALTH INSTITUTE Finlandia Contributo UE Nessun dato Indirizzo Neulaniementie 4 70701 KUOPIO Mostra sulla mappa Costo totale Nessun dato SCHOOL OF VETERINARY MEDICINE, HANNOVER Germania Contributo UE Nessun dato Indirizzo Buenteweg 17 30559 HANNOVER Mostra sulla mappa Costo totale Nessun dato UNIVERSITE LOUIS PASTEUR, STRASBOURG 1 Francia Contributo UE Nessun dato Indirizzo Rue Blaise Pascal 4 67070 STRASBOURG Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF OULU Finlandia Contributo UE Nessun dato Indirizzo Pentti Kaiterankatu 1 90014 OULU Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato