Cel The proposed project is designed to investigate the implication and interaction of the basal ganglia (BG) and the cerebellum in different movement disorders. Beyond the role attributed to the BG in the pathophysiology of movement disorders, the cerebellum is also known to be involved in motor control and non-motor tasks such as mental imagery, sensory processing, planning, attention and language. However, the exact mechanisms such a control under normal and pathophysiological conditions are not clear. Studi es in patients suffering from Parkinson's disease (PD) using positron emission tomography have suggested the implication and interaction of both the cortico-BG-thalamocortical loop and the cerebello-thalamocortical pathway in the pathophysiology of PD. Mor eover, compensatory mechanisms delaying the onset of PD symptoms are expected to reside in the cerebello-thalamocortical pathway. Beyond the implication of the cerebellum in the pathophysiology of PD, it has been reported that modifications in cerebellar a ctivity also occur in other movement disorders such as multiple system atrophy (MSA), dystonia, Huntington's disease (HD) and essential tremor. The objectives are (i) to understand the implication and interaction of BG and cerebellum in different movement disorders such as PD, MSA, dystonia and HD, (ii) to identify compensatory mechanisms residing in cerebello-thalamocortical pathways and (iii) to determine mechanisms of action of high frequency stimulation implicating BG and cerebellum. These objectives wi ll be achieved using complementary techniques (2-deoxyglucose activity, in situ hybridisation of different neuronal markers, microdialysis and HPLC). In the longer term, these techniques will be extended by extracellular multi¬ channel recordings and beha viour (motor and cognitive component tasks). The expected results will improve our pathophysiological comprehension of disabling movement disorders with high socio-# Dziedzina nauki medical and health sciencesbasic medicinephysiologypathophysiologymedical and health sciencesbasic medicineneurologyparkinson Program(-y) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Temat(-y) MOBILITY-4.1 - Marie Curie European Reintegration Grants (ERG) Zaproszenie do składania wniosków FP6-2002-MOBILITY-11 Zobacz inne projekty w ramach tego zaproszenia System finansowania ERG - Marie Curie actions-European Re-integration Grants Koordynator HUMBLODT UNIVERSITAET ZU BERLIN - UNIVERSITAETSKLINIKUM CHARITE Wkład UE Brak danych Adres Schumanstrasse 20-21 BERLIN Niemcy Zobacz na mapie Koszt całkowity Brak danych
