Cel The neural assembly underlying the formation of functional networks in the cerebral cortex constitutes one of the most complex neuronal systems in the brain. Much of this complexity arises during development through the interaction of two distinct neuronal types, the glutamatergic projection neurons and g-aminobutyric containing (GABAergic) interneurons. Recently, interneuron dysfunction has been associated with severe neurological and psychiatric disorders (e.g. epilepsy, schizophrenia and bipolar disorder). In order to achieve true progress in the understanding of cortical development and of neurological diseases associated with cortical interneuron dysfunction, a complete account of the development of its neuronal constituents is essential. In that sense, despite the detailed picture that is emerging about the development of cortical projection neurons, the mechanisms underlying the development of interneurons in the cerebral cortex have remained poorly defined. The general goal of the network is to obtain a comprehensive definition of the cellular and molecular mechanisms controlling the development of cortical interneurons. To reach this aim, we will take a multidisciplinary approach by combining novel bioinformatic and genomics applications, cutting-edge imaging techniques, and conventional cellular, molecular and electrophysiological methodologies. In addition, we will develop new genetic tools to engineer developmental models of cortical disorders involving interneuron deficiency. Thus, successful execution of the project will result in: i) New knowledge of the mechanisms underlying the specification, migration and terminal differentiation of cortical interneurons, and ii) Generation of new developmental models of cortical disorders resulting from interneuron deficiency. Dziedzina nauki medical and health sciencesbasic medicineneurologyepilepsymedical and health sciencesclinical medicinepsychiatryschizophrenianatural sciencesbiological sciencesgeneticsgenomes Słowa kluczowe Cerebral cortex GABA cell-therapy cortical disorders development epilepsy genomics microarrays migration mouse genetics mouse models neuron patterning schizophrenia synaptogenesis therapy Program(-y) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) LSH-2003-2.1.3-5 - Cortical development Zaproszenie do składania wniosków FP6-2003-LIFESCIHEALTH-I Zobacz inne projekty w ramach tego zaproszenia System finansowania STREP - Specific Targeted Research Project Koordynator CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Wkład UE Brak danych Adres Serrano 117 MADRID Hiszpania Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (7) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko FOUNDATION FOR RESEARCH AND TECHNOLOGY - HELLAS Grecja Wkład UE Brak danych Adres Vassilika Vouton 1527 HERAKLION Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych MEDICAL RESEARCH COUNCIL Zjednoczone Królestwo Wkład UE Brak danych Adres 20 Park Crescent LONDON Zobacz na mapie Koszt całkowity Brak danych CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francja Wkład UE Brak danych Adres 3 Rue Michel-Ange PARIS Zobacz na mapie Koszt całkowity Brak danych ORYZON GENOMICS SA Hiszpania Wkład UE Brak danych Adres PARC CIENTIFIC DE BARCELONA - C/ JOSEP SAMITIER 1 BARCELONA Zobacz na mapie Koszt całkowity Brak danych UNIVERSIDAD MIGUEL HERNANDEZ Hiszpania Wkład UE Brak danych Adres Avda. de la Universidad s/n ELCHE, ALICANTE Zobacz na mapie Koszt całkowity Brak danych FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO RAMÓN Y CAJAL Hiszpania Wkład UE Brak danych Adres Ctra Colmenar Km 9 Planta -2D MADRID Zobacz na mapie Koszt całkowity Brak danych FONDAZIONE TELETHON Włochy Wkład UE Brak danych Adres VIA SALICETO, 5 ROME Zobacz na mapie Koszt całkowity Brak danych