Cel The aim of VIAV is to develop a highly innovative Env-based vaccine capable of inducing cross-clade neutralizing antibodies to prevent HIV infection.This represents the most important problem of current Env-based vaccines.VIAV aim will be achieved through new antigen design stemming out from novel virological, immunological and modeling data of the VIAV Consortium indicating that Tat increases HIV cell adsorption, infectivity and tropisms via a molecular mimicry of the CCR5 co-receptor.In fact,Tat binds the V3 loop of the HIV Env at the same residues binding the CCR5,allowing the generation and stabilization of complexes presenting cryptic and/or transiently exposed Env epitopes.These are crucial for inducing cross-clade neutralizing antibodies. In addition , R5 viruses are the major virus phenotype transmitted to healthy individuals.The goal of VIAV will be fulfilled through the achievement of specific objectives which, in turn, are the focus of specific workpackages: 1.Characterization of the Tat/V3loop com plex through the combined application of bioinformatics tools, NMR studies and microcalorimetry measurements 2.Generation,chemical-physical,immunological and biological characterization of Tat/Env complexes and their formulation for in vitro and in vivo s tudies 3.Evaluation of the safety and immunogenicity of different Tat/Env complex-based vaccine formulations in small animal models 4.Characterization of the specificity of the antibody responses generated in immunized animals 5.Characterization of virus-s pecific and cross-clade neutralizing activity of antibodies generated in immunized animals. The achievement of VIAV objectives will be implemented through a rigorous management of the scientific, business and administrative activities by the Steering Commi ttee and by the Project Coordinator. VIAV is linked to the AIDS Vaccine Integrated Project (AVIP),recently awarded by the EU Commission, for future product development and clinical testing Dziedzina nauki natural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Słowa kluczowe AIDS Env HIV HIV entry HIV neutralizing antibodies Tat Env complex Tat protein rational design of new immunogens Program(-y) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) LSH-2003-2.3.0-1 - Highly innovative approaches for the development of new interventions for HIV, malaria and tuberculosis Zaproszenie do składania wniosków FP6-2003-LIFESCIHEALTH-3 Zobacz inne projekty w ramach tego zaproszenia System finansowania STREP - Specific Targeted Research Project Koordynator ISTITUTO SUPERIORE DI SANITÀ Wkład UE Brak danych Adres Viale Regina Elena 299 ROME Włochy Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (8) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLOPROTEINE PARAMAGNETICHE Włochy Wkład UE Brak danych Adres Via Luigi Sacconi 6 SESTO FIORENTINO Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych DIATHEVA S.R.L. Włochy Wkład UE Brak danych Adres Viale Piceno 137/F FANO Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych LUNDS UNIVERSITET Szwecja Wkład UE Brak danych Adres Paradisgatan 5 C LUND Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych TERRAMATICA CONSULTING SRL Włochy Wkład UE Brak danych Adres Via Giovanni Missori, 15 ROME Zobacz na mapie Koszt całkowity Brak danych UNIVERSITETET I BERGEN Norwegia Wkład UE Brak danych Adres Muséplass 1 BERGEN Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITY OF FERRARRA Włochy Wkład UE Brak danych Adres Via Savonarola 9 FERRARA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITY OF PADUA Włochy Wkład UE Brak danych Adres Via 8 Febbraio 2 PADUA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITY OF URBINO "CARLO BO" Włochy Wkład UE Brak danych Adres Via Saffi 2 URBINO Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
