Objective
The overall aim of this program is to assess the role of mitochondrial function in ageing and life span control. The strategy that we shall use is to discover mechanisms that show evolutionary conservation between invertebrate and mammalian model systems. We will use a unique matrix of model organisms (yeast, Podospora anserina, Caenorhabditis elegans, Drosophila melanogaster, mouse and rat) and cell culture systems. Specific questions will be experimentally tested. The following age-related issues are addr essed: (i) modulation of mitochondrial reactive oxygen species (ROS) by different means, (ii) relevance of molecular and cellular pathways to maintain a "healthy" population of mitochondria, (iii) nature and impact of signalling pathways on mitochondrial a ctivity, (iv) effects of dietary restriction on mitochondrial activity, (v) novel age-related mitochondrial functions. The participating laboratories have a strong commitment for collaborative work and ideally complement each other. Some of the partners ex tensively collaborated in the past or are collaborating presently in the field of research addressed in this IP. They are working with different model organisms and systems, most are well experienced in the field of experimental biogerontology, and they ea ch have a specific expertise in different fields of research ranging from advanced biochemistry, cytology, genetics to molecular biology. This consortium will be in the unique situation to perform competitive research with other programs in the world aimed to identify and characterize mechanisms of ageing that are conserved in most species, hence called 'public' mechanisms of ageing. At the same time, the IP will complement European activities that follow other strategies (e.g. comparing mitochondrial para meters from human tissues of different human populations) to elucidate the role of mitochondria in human ageing.'
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences basic medicine physiology cytology
- natural sciences biological sciences molecular biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-LIFESCIHEALTH-I
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
FRANKFURT AM MAIN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.