Objetivo The tremendous success with which antibiotics have been used to combat infectious diseases is under serious threat from the increasing development of antimicrobial resistance. Without new treatment approaches to address antimicrobial resistance, this threa t will continue to rise. To fight infectious diseases effectively in the future we have to broaden the approaches in therapeutic intervention. There are three ways along which the therapeutic intervention of infectious diseases can be broadened. The first is to design drugs that have a smaller chance for resistance-development (to target evolutionary conserved structures is one key element here). The second is to design drugs that are as different in mechanism of action as we can envision. The third is to c ombine drugs. AMIS (Antimicrobials by Immune Stimulation) combines these three strategies in a highly innovative approach. AMIS aims to use the strength of our own innate immune system to design antimicrobial drugs for future generations. Antimicrobial pr oteins in our immune system are often combined with inflammatory signals in one single molecule. AMIS will take that same approach and reshuffle different parts of different molecules to make novel effector molecules that still have these combined function s but are optimally adapted for therapeutic intervention. Within our innate immune system many molecules have been identified over the last years that are involved in direct or indirect clearance of bacteria. The consortium will select the most promising and innovative compounds with this dual mode of action and: - Design proteins with anti-microbial activity in combination with an inflammatory trigger, targeting extra cellular bacteria; - Design proteins with inflammatory priming capacity (without extra anti-microbial activity); targeting intracellular bacteria; - Discover new TLR and PGRP and FPR modulators to dampen inflammation. Ámbito científico natural sciencesbiological sciencesmicrobiologybacteriologymedical and health scienceshealth sciencesinfectious diseasesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Palabras clave Immune stimulation Novel antimicrobial approach fusion compounds Programa(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Tema(s) LSH-2003-2.1.2-3 - Novel approaches to address antimicrobial resistance through non-antimicrobial based therapies Convocatoria de propuestas FP6-2003-LIFESCIHEALTH-I Consulte otros proyectos de esta convocatoria Régimen de financiación STREP - Specific Targeted Research Project Coordinador UNIVERSITY MEDICAL CENTRE UTRECHT Aportación de la UE Sin datos Dirección Heidelberglaan 100 UTRECHT Países Bajos Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Participantes (8) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITY OF COLOGNE Alemania Aportación de la UE Sin datos Dirección Goldenfelsstrasse 19-21 KÖLN Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY Noruega Aportación de la UE Sin datos Dirección Hogskoleringen 1 TRONDHEIM Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos LUND UNIVERSITY Suecia Aportación de la UE Sin datos Dirección Paradisgatan 5C LUND Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos UTRECHT UNIVERSITY; FACULTY OF VETERINARY MEDICINE Países Bajos Aportación de la UE Sin datos Dirección Yalelaan 1 UTRECHT Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos UNIVERSITY OF DEBRECEN Hungría Aportación de la UE Sin datos Dirección Egyem ter. 1 DEBRECEN Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos IQ CORPORATION B.V. Países Bajos Aportación de la UE Sin datos Dirección Rozenburglaan 13a GRONINGEN Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos TARGET-IN LTD. Israel Aportación de la UE Sin datos Dirección 33 Lamed-Hei street KFAR-SABA Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos UNIVERSITY HOSPITAL TÜBINGEN Alemania Aportación de la UE Sin datos Dirección Elfriede-Aulhom-Strasse 6 TÜBINGEN Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos
