Objectif The aim of this proposal is to develop experimental models to investigate the effects of mixtures of persistent pollutants present in food on the developing nervous system. Major objectives are to: 1. Develop standardised testing protocols based on the use of multiple in vitro experimental models. 2. Identify specific biochemical, molecular and functional end-points based on the mechanism of action of specific neurotoxicants, both alone and in combination. 3. Evaluate the neurotoxic effects of the selected substances during development and the long-term consequences, with special attention to gender-related aspects. 4. Define quantitative measures of observed effects for risk-assessment purposes, and incorporate currently available human and animal data to derive guidelines and exposure limits as gold standards. The complexity of the topic and its aims require the use of relevant experimental approaches and the evaluation of a wide range of mechanism-based parameters on a panel of selected experimental models representing possible targets for the selected toxicants. The project uses a multidisciplinary approach, combining in vitro and in vivo experimental strategies, stretching from single-cell analyses to the analysis of behaviour. The dose- dependent effects of persistent pollutants, such as PCBs and methylmercury, on the developing nervous system and the long-term consequences will be evaluated. All these chemicals are well-known neurotoxicants, targeting different cell populations via mechanisms of action that are not fully understood. In addition, there is a lack of studies on the neurotoxic effects of simultaneous exposure to low doses on the multiple targets that are affected by these compounds, especially related to gender aspects. The results of our work will generate novel information about the interactions of the selected neurotoxicants, as well as relevant experimental approaches to investigate the effects... Champ scientifique natural sciencesbiological sciencesneurobiologycognitive neurosciencemedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicinetoxicology Programme(s) FP6-FOOD - Food Quality and Safety: Thematic priority 5 under the Focusing and Integrating Community Research programme 2002-2006. Thème(s) FOOD-2002-T43 - Neurotoxic effects of environmental contaminants Appel à propositions FP6-2002-FOOD-1 Voir d’autres projets de cet appel Régime de financement STREP - Specific Targeted Research Project Coordinateur KAROLINSKA INSTITUTET - KI Contribution de l’UE Aucune donnée Adresse Solnavägen 1 STOCKHOLM Suède Voir sur la carte Coût total Aucune donnée Participants (8) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITA DEGLI STUDI DI PAVIA[DUPLI:999013470] Italie Contribution de l’UE Aucune donnée Adresse VIA ESPIFANIO 17 PAVIA Voir sur la carte Coût total Aucune donnée UNIVERSITA DEGLI STUDI DI PARMA Italie Contribution de l’UE Aucune donnée Adresse Via Universita 12 PARMA Voir sur la carte Coût total Aucune donnée FUNDACION VALENCIANA DE INVESTIGACIONES BIOMEDICAS - INSTITUTO DE INVESTIGACIONES CITOLOGICAS Espagne Contribution de l’UE Aucune donnée Adresse Amadeo de Saboya 4 VALENCIA Voir sur la carte Coût total Aucune donnée UNIVERSITE CATHOLIQUE DE LOUVAIN Belgique Contribution de l’UE Aucune donnée Adresse Place de l'Université 1 LOUVAIN-LA-NEUVE Voir sur la carte Coût total Aucune donnée UPPSALA UNIVERSITET Suède Contribution de l’UE Aucune donnée Adresse St Olofsgatan, 10B 256 UPPSALA Voir sur la carte Coût total Aucune donnée NOFER INSTITUTE OF OCCUPATIONAL MEDICINE Pologne Contribution de l’UE Aucune donnée Adresse Teresy Street 8 199 LODZ Voir sur la carte Coût total Aucune donnée UNIVERSITA DI BARI Italie Contribution de l’UE Aucune donnée Adresse Via Orabona 4 BARI Voir sur la carte Coût total Aucune donnée THE PROVOST FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN Irlande Contribution de l’UE Aucune donnée Adresse College Green DUBLIN Voir sur la carte Coût total Aucune donnée