Objective The goal is a nano-technology platform based on a 100 nm size grid of addressable molecular building blocks, a novel bottom-up modular approach to place functional groups at defined positions in space with sub-nm precision. An almost complete freedom of ch oice, for grid assembly as well as for positioning of functional groups is based on a "digital" code for molecular recognition. The project involves very demanding synthetic and physico-chemical tasks: on the other hand, if successful the reward is enormou s as it can provide a basis for a range of forceful nanotechnological applications (it might even become the basis for future nanotechnology!). High structural fidelity and convenient assembly rates are achieved using DNA base-pair recognition and stacking into rigid double-helical structures. Each node has typically three oligonucleotide strands and a moiety for attachment of either a functional group or a lipid anchoring group, so that a group of six nodes are connected into a hexagon (energetically favou rable) providing a planar network of hexagons. Further kinetic robustness may be achieved. The partners represent the ultimate expertise in Europe in synthetic and supramolecular chemistry and in biophysical, colloidal and photophysical chemistry, needed f or the joint venture: 1. Synthetic strategy for node building blocks. 2. Tuning interactions and reaction rates to ascertain correct assembly into grid attached to lipid support. 3. Positioning of functional groups. 4. Analytical tools to follow assembly a nd verify structures. From here various applied projects will take over, attaching interesting functional groups at pre-determined positions on the grid map, and supramolecular structures extending perpendicular to the grid surface, into the 3rd dimension. The proposal fits well the call, being a novel bottom-up approach to achieve self-organising nanostructures with high resolution and control of properies and performance. Fields of science natural sciencesbiological sciencesgeneticsDNAengineering and technologynanotechnologynatural sciencesphysical sciencesopticsmicroscopynatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsnatural scienceschemical scienceselectrochemistryelectrophoresis Keywords Nanotechnology Programme(s) FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006. Topic(s) NMP-2003-3.4.1.1-1 - Self-organisation and elf-assembling Call for proposal FP6-2003-NMP-TI-3-MAIN See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator CHALMERS TEKNISKA HÖGSKOLA AB EU contribution No data Address Chalmersplatsen 4 GOTHENBURG Sweden See on map Links Website Opens in new window Total cost No data Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITY OF SOUTHAMPTON United Kingdom EU contribution No data Address Highfield SOUTHAMPTON See on map Links Website Opens in new window Total cost No data CONSORZIO PER LO SVILUPPO DEI SISTEMI A GRANDE INTERFASE, UNIVERSITA' DI FIRENZE' Italy EU contribution No data Address via della Lastruccia 3, Sesto Fiorentino FIRENZE See on map Links Website Opens in new window Total cost No data UNIVERSITÉ LOUIS PASTEUR France EU contribution No data Address 4, Rue Blaise Pascal STRASBOURG See on map Links Website Opens in new window Total cost No data
