Objectif The establishment of non-invasive markers for prenatal diagnosis and is a very important research goal. Current invasive procedures have (1) a significant risk of induced abortion (1-2%) or maternal injury and (2) considerable discomfort and psychological distress. The overall objective of this project is to exploit breakthroughs at the confluences of bio-, micro- and nano- technologies to create a low-cost non-invasive intelligent diagnosis system using a nanotechnology-based device for the isolation, enrichment and detection of foetal cells from maternal blood so as to facilitate non-invasive pre-natal diagnosis. Advances in molecular biology and biosensor technology and the integration of nanostructured functional components in macro and microsystems will facilitate the separation of foetal cells from maternal cells on the basis of cell size, deformability, surface chemistry, novel markers, and charge. Addressing health care requirements of the future of an individualised theranostic approach, the specific application that will be demonstrated will be the isolation of foetal cells with the platform technology being applicable to the isolation of early cancer cells as well as stem cells in peripheral blood. The proposed technology is highly ambitious in nature and meets the ADVENTURE requirements of being a visionary, far-reaching, multidisciplinary project, that contributes substantially to the state-of-the-art with novel technologies of immense impact, with potential applications in non-invasive prenatal diagnostics, cancer diagnostics and theranostics and isolation of stem cells, not to mention the second tier ofsimpler devices exploiting some of the proposed modules for POC diagnostics, environmental and food quality control monitoring. The proposed technology does not fall directly within the domains of research of the FP6 thematic priorities. Champ scientifique engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensorsmedical and health sciencesclinical medicineobstetricsfetal medicinemedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesmolecular biology Mots‑clés Biosensors Nanotechnology Non-invasive prenatal diagnosis Risk Assessment theranostics Programme(s) FP6-POLICIES - Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Thème(s) NEST-2003-1 - Adventure activities Appel à propositions FP6-2003-NEST-A Voir d’autres projets de cet appel Régime de financement STREP - Specific Targeted Research Project Coordinateur UNIVERSITAT ROVIRA I VIRGILI Contribution de l’UE Aucune donnée Adresse c/ de l'Escorxador s/n TARRAGONA Espagne Voir sur la carte Coût total Aucune donnée Participants (6) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire INSTITUT FUER MIKROTECHNIK MAINZ GMBH Allemagne Contribution de l’UE Aucune donnée Adresse Carl-Zeiss-Strasse 18-20 MAINZ Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France Contribution de l’UE Aucune donnée Adresse 101 rue de Tolbiac PARIS Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée UNIVERSITY OF NEWCASTLE UPON TYNE Royaume-Uni Contribution de l’UE Aucune donnée Adresse 6 KENSINGTON TERRACE NE1 7RU NEWCASTLE UPON TYNE Voir sur la carte Coût total Aucune donnée UNIVERSITY OF THE WEST OF ENGLAND, BRISTOL Royaume-Uni Contribution de l’UE Aucune donnée Adresse Frenchay Campus, Coldharbour Lane BRISTOL Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée UNIVERSITY OF WARWICK Royaume-Uni Contribution de l’UE Aucune donnée Adresse Gibbet Hill road COVENTRY Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER Allemagne Contribution de l’UE Aucune donnée Adresse Schlossplatz 2 MUENSTER Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée
