Objetivo Malaria is one of the three major infectious diseases. Although the disease is prevalent in the tropics and subtropics it has caused a global emergency. 300-400 million cases with 1-2 million deaths per year and rapidly increasing resistance to antimalarial drugs call for focused novel strategies on combating malaria. Transport proteins for nutrients and metabolites of the minimal parasite/host interface are getting into the focus of the current search for novel antimalarial targets. MalariaPorin is an interdisciplinary project that wants to take genomic information to drug development. The chief goal is to decide on the question whether the Plasmodium water and glycerol channel, aquaglyceroporin, of the parasite/host interface is a suitable drug target for chemotherapy. Concurrently, the conditions for generating aquaglyceroporin inhibitory drugs are developed. To achieve these goals, a multidisciplinary approach is taken covering a) thorough studies on the physiological role of water and glycerol transport in the malaria parasite including the generation of deletion strains; b) establishment of robust and practical assay systems for compound testing based on Xenopus laevis oocytes, yeast and P. falciparum parasites; c) determination from field isolates of the occurrence and functional consequences of polymorphisms of the aquaglyceroporin gene; d) generation of protein structure models and elucidation of the 3D structure from protein crystallisation for solving mechanistic questions on the channel selectivity and for virtual drug design; e) design and synthesis of compound libraries based on the knowledge of other aquaporin blockers and biochemical studies of substrate specificity. It is envisioned that MalariaPorin may become the starting point for a wider strategy to assess the role of aquaporins in pathogenic parasites, such as Toxoplasma gondii and Trypanosoma brucei and cruzi, and their potential use as drug targets. Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health scienceshealth sciencesinfectious diseasesmalariamedical and health sciencesbasic medicinemedicinal chemistrynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesbiochemistrybiomoleculeslipids Programa(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Tema(s) LIFESCIHEALTH-2.3.0 - Developing new promising candidate vaccines and therapies Convocatoria de propuestas FP6-2003-LIFESCIHEALTH-3 Consulte otros proyectos de esta convocatoria Régimen de financiación STREP - Specific Targeted Research Project Coordinador CHRISTIAN-ALBRECHTS-UNIVERSITY OF KIEL Aportación de la UE Sin datos Dirección Olshausenstr. 40 KIEL Alemania Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Participantes (6) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo GOTEBORG UNIVERSITY Suecia Aportación de la UE Sin datos Dirección Vasaparken 100 GOTEBORG Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos THE UNIVERSITY OF EDINBURGH Reino Unido Aportación de la UE Sin datos Dirección Old College, South Bridge EDINBURGH Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Alemania Aportación de la UE Sin datos Dirección Hofgartenstrasse 8 MUENCHEN Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE Estados Unidos Aportación de la UE Sin datos Dirección 725 N. Wolfe Street BALTIMORE, MD Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos THE UNIVERSITY OF MANCHESTER Reino Unido Aportación de la UE Sin datos Dirección Oxford Road MANCHESTER Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos EBERHHARD-KARLS-UNIVERSITÄT TÜBINGEN Alemania Aportación de la UE Sin datos Dirección Wilhelmstr. 5 TUEBINGEN Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos