Objectif TB is one of the most deadly infectious disease in the world. The high rates of patient non-compliance lead to more than three million deaths per year, as well as, to the creation of chronic, infectious, drug-resistant TB strains, against which almost all existing antibiotics are ineffective or prohibitively toxic. A short course of chemotherapy (two months or less) would significantly increase patient compliance, substantially reduce the rate of emergence of antibiotic resistance, decrease side-effects of treatment, and materially decrease the costs of treatment.We have made four scientific breakthroughs which indicate that it is feasible to develop such a drug:1. As part of a research project supported by the EC, we have recently solved the 3-D structure of several persistence related drug targets of M. tuberculosis. We have obtained information on ligands which shall be directly submitted to lead optimization pipeline.2. Our work has shown that persistent M. tuberculosis is metabolically active, and thus should be susceptible to specific chemotherapy, albeit different from current antibiotics.3. New assays have been developed for screening drugs which kill persistent M.tuberculosis. These assays can distinguish between drugs such as isoniazid which have little action against persisters, and compounds which are known to have some anti-persister activity such as pyrazinamide.4. We have identified unique compounds which kill M.tuberculosis including Rifampicin resistant strains. In the current project, we plan to apply our integrated strategy to the drug development pipeline by structural analysis of novel targets, virtual and real screening based identification of leads, new organic synthetic chemistry and functional evaluation in mice.The outcome of this project is expected to lead to new drugs which will shorten the duration of TB treatment, will improve the treatment of latent TB infection and are effective against multi-drug resistant TB. Champ scientifique medical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesclinical medicinepneumologytuberculosismedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistancemedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Thème(s) LSH-2004-2.3.0-7 - Research in poverty-related diseases by SMEs Appel à propositions FP6-2004-LIFESCIHEALTH-5 Voir d’autres projets de cet appel Régime de financement STREP - Specific Targeted Research Project Coordinateur LIONEX DIAGNOSTICS & THERAPEUTICS GMBH Contribution de l’UE Aucune donnée Adresse Mascheroder Weg 1b BRAUNSCHWEIG Allemagne Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (5) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire GESELLSCHAFT FUER BIOTECHNOLOGISCHE FORSCHUNG MBH Allemagne Contribution de l’UE Aucune donnée Adresse Mascheroder Weg 1 BRAUNSCHWEIG Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée KAROLINSKA INSTITUTET Suède Contribution de l’UE Aucune donnée Adresse Nobels vag 5 STOCKHOLM Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée ST GEORGE'S HOSPITAL MEDICAL SCHOOL Royaume-Uni Contribution de l’UE Aucune donnée Adresse Cranmer Terrace LONDON Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée UNIVERSITY COLLEGE LONDON Royaume-Uni Contribution de l’UE Aucune donnée Adresse Gower Street LONDON Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée UNIVERSITY OF HANOVER Allemagne Contribution de l’UE Aucune donnée Adresse Schneiderberg 1B HANNOVER Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée