Obiettivo The goal of this project is to develop low-cost, label-free biomolecular detectors/sentinels by integrating concepts and methods from bionanotechnology and microelectronics. More specifically, the project aims to design, fabricate, test and validate a biomorphic hybrid technology by which biological self-assembling structures are interfaced with advanced electronic circuits for signal detection, amplification and conditioning. So doing, we exploit the strength of biotechnology to achieve a very high sensitivity and selectivity, as well as the great potential of micro- and nano-electronics to address system miniaturization, low-power consumption, and low cost. The approach is based on arrays of independent and electrically addressable micro-spots where functional lipid bilayers are self-assembled either in structured micron- scale apertures, or in artificial nanometric pores. Membrane functionalization is determined by embedding bioengineered ion channels or receptors in the lipid bilayers, to achieve highly specific interactions with target molecules. The array is organized so as to couple each spot with a smart and miniaturized electronic interface for the detection, amplification and conditioning of the signals produced by the transmembrane ion fluxes induced by the target molecules. An additional goal of this approach is to boost the overall system performance by means of advanced data processing and storage architectures. An important objective of the proposal will be the evaluation and the assessment of the technology as a valuable platform in health applications with respect to state of the art counterparts. For this purpose, validation exercises will be undertaken within the program, using different kinds of receptors for several applications. Campo scientifico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsnatural sciencesphysical scienceselectromagnetism and electronicsmicroelectronicsnatural scienceschemical sciencesinorganic chemistrymetalloidsnatural sciencescomputer and information sciencesdata sciencedata processing Parole chiave Nanotechnology Risk Assessment Programma(i) FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006. Argomento(i) NMP-2004-IST-NMP-2 - Bio-sensors for Diagnosis and Healthcare Invito a presentare proposte FP6-2004-IST-NMP-2 Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA Contributo UE Nessun dato Indirizzo Via Zamboni 33 BOLOGNA Italia Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (6) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto SILICON BIOSYSTEMS SPA Italia Contributo UE Nessun dato Indirizzo Viale Ercolani 3 BOLOGNA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato COMMISSARIAT A L'ENERGIE ATOMIQUE (CEA) Francia Contributo UE Nessun dato Indirizzo 31-33 rue de la Fédération PARIS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Francia Contributo UE Nessun dato Indirizzo 3, Rue Michel-Ange PARIS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF SOUTHAMPTON Regno Unito Contributo UE Nessun dato Indirizzo University Road, Highfield SOUTHAMPTON Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS Grecia Contributo UE Nessun dato Indirizzo Christou Lada 6 ATHENS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato SOCIÉTÉ DE PHARMACOLOGIE ET D'IMMUNOLOGIE-BIO Francia Contributo UE Nessun dato Indirizzo Avenue Ampere, 10 bis MONTIGNY-LE BRETONNEUX Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato
