Objective
Breast cancers are prone to metastasise, particularly to the lymphatics, bone, liver, lungs and central nervous system tissues. Once solid secondary tumours are established, the chances of long-term survival fall from over 90% to around 5%. The proposed STREP project "METABRE" will investigate the molecular mechanisms of breast cancer metastasis, including the identification and functional analysis of new genes and proteins that characterise the organ-specific metastatic phenotype in breast cancer cells, and the interaction of cancer cells with the affected organ tissues. METABRE will then develop new pharmacological therapies to prevent or treat metastases, and new diagnostic techniques, based on the identification and characterisation of molecular targets implicated in breast cancer metastasis. The project workplan has eleven workpackages for gene profiling and proteomic analysis of tissue samples, functional analysis of newly identified genes and proteins, mechanisms of angiogenesis and invasion, organ-cancer cell interactions, development of pharmacological therapies, development of diagnostic techniques, and preliminary clinical trials of the diagnostic techniques and one of the therapies under development. The consortium has 12 partners from 8 countries and includes leading academic groups in the metastasis field and 2 pharmaceutical companies. The project achieves the necessary critical mass in terms of personnel, scientific expertise, experimental models and finance in order to meet the objectives.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology breast cancer
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
L'AQUILA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.