Obiettivo Breast cancers are prone to metastasise, particularly to the lymphatics, bone, liver, lungs and central nervous system tissues. Once solid secondary tumours are established, the chances of long-term survival fall from over 90% to around 5%. The proposed STREP project "METABRE" will investigate the molecular mechanisms of breast cancer metastasis, including the identification and functional analysis of new genes and proteins that characterise the organ-specific metastatic phenotype in breast cancer cells, and the interaction of cancer cells with the affected organ tissues. METABRE will then develop new pharmacological therapies to prevent or treat metastases, and new diagnostic techniques, based on the identification and characterisation of molecular targets implicated in breast cancer metastasis. The project workplan has eleven workpackages for gene profiling and proteomic analysis of tissue samples, functional analysis of newly identified genes and proteins, mechanisms of angiogenesis and invasion, organ-cancer cell interactions, development of pharmacological therapies, development of diagnostic techniques, and preliminary clinical trials of the diagnostic techniques and one of the therapies under development. The consortium has 12 partners from 8 countries and includes leading academic groups in the metastasis field and 2 pharmaceutical companies. The project achieves the necessary critical mass in terms of personnel, scientific expertise, experimental models and finance in order to meet the objectives. Campo scientifico natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncologybreast cancernatural sciencesmathematicspure mathematicsmathematical analysisfunctional analysis Parole chiave breast cancer gene profiling metastasis organ organ-specific Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2002-2.2.0-8 - Translational research on promising predictive and prognostic markers LSH-2002-2.2.0-7 - Molecular mechanisms involved in organ-specific metastatic growth processes in breast cancer Invito a presentare proposte FP6-2002-LIFESCIHEALTH Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore UNIVERSITA DEGLI STUDI DE L'AQUILA Contributo UE Nessun dato Indirizzo Piazza Vincenzo Rivera 1 L'AQUILA Italia Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (12) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto CANCERTEK PHARMACEUTICALS LTD Israele Contributo UE Nessun dato Indirizzo Dov Hoz St, 8 KIRIAT-ONO Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato CENTRE RENE HUGUENIN Francia Contributo UE Nessun dato Indirizzo 35 rue Dailly ST CLOUD Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato CONSORZIO MARIO NEGRI SUD Italia Contributo UE Nessun dato Indirizzo VIA NAZIONALE, 1 SANTA MARIA IMBARO Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato FUNDACIO INSTITUT DE RECERCA ONCOLOGICA Spagna Contributo UE Nessun dato Indirizzo Gran Via s/n 2,7 HOSPITALET DEL LLOBREGAT, BARCELONA Mostra sulla mappa Costo totale Nessun dato FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE Spagna Contributo UE Nessun dato Indirizzo Feixa Llarga s/n L'HOSPITALET DE LLOBREGAT Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francia Contributo UE Nessun dato Indirizzo 101, rue de Tolbiac PARIS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL Regno Unito Contributo UE Nessun dato Indirizzo OLD BROMPTON ROAD 123 LONDON Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato LEIDEN UNIVERSITY MEDICAL CENTER Paesi Bassi Contributo UE Nessun dato Indirizzo Albinusdreef 2 9600 LEIDEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato PROSKELIA SAS Francia Contributo UE Nessun dato Indirizzo Route de Noisy 102 ROMAINVILLE Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITE DE LIEGE Belgio Contributo UE Nessun dato Indirizzo Place du 20 Août, 7 LIÈGE Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITEIT GENT Belgio Contributo UE Nessun dato Indirizzo Sint Pietersnieuwstraat 25 GENT Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato WROCLAW UNIVERSITY OF ENVIRONMENTAL AND LIFE SCIENCES Polonia Contributo UE Nessun dato Indirizzo C.K. Norwida 31 WROCLAW Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato