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MOLECULAR MECHANISMS INVOLVED IN ORGAN-SPECIFIC METASTATIC GROWTH PROCESSES IN BREAST CANCER

Obiettivo

Breast cancers are prone to metastasise, particularly to the lymphatics, bone, liver, lungs and central nervous system tissues. Once solid secondary tumours are established, the chances of long-term survival fall from over 90% to around 5%. The proposed STREP project "METABRE" will investigate the molecular mechanisms of breast cancer metastasis, including the identification and functional analysis of new genes and proteins that characterise the organ-specific metastatic phenotype in breast cancer cells, and the interaction of cancer cells with the affected organ tissues. METABRE will then develop new pharmacological therapies to prevent or treat metastases, and new diagnostic techniques, based on the identification and characterisation of molecular targets implicated in breast cancer metastasis. The project workplan has eleven workpackages for gene profiling and proteomic analysis of tissue samples, functional analysis of newly identified genes and proteins, mechanisms of angiogenesis and invasion, organ-cancer cell interactions, development of pharmacological therapies, development of diagnostic techniques, and preliminary clinical trials of the diagnostic techniques and one of the therapies under development. The consortium has 12 partners from 8 countries and includes leading academic groups in the metastasis field and 2 pharmaceutical companies. The project achieves the necessary critical mass in terms of personnel, scientific expertise, experimental models and finance in order to meet the objectives.

Invito a presentare proposte

FP6-2002-LIFESCIHEALTH
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Coordinatore

UNIVERSITA DEGLI STUDI DE L'AQUILA
Contributo UE
Nessun dato
Indirizzo
Piazza Vincenzo Rivera 1
L'AQUILA
Italia

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Collegamenti
Costo totale
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Partecipanti (12)