Cel Intracellular communication in eukaryotes is largely achieved by the trafficking of membranes carrying membrane-bound and/or intravesicular signalling molecules.Inside cells, vesicles circulate from one intracellular compartment to another thus facilitating vectorial transport of signals.Between cells, membrane anchored and secreted soluble molecules mediate extracellular signalling.Exocytosis and endocytosis of receptors control the response of sensitive cells to extracellular signals.The routes of membrane trafficking are controlled by cell signalling pathways but the underlying molecular machinery is scarcely characterised. Moreover, membrane trafficking has been studied mainly in differentiated cells and rarely in cells changing phenotype during differentiation or dedifferentiation.Such drastic phenotypic changes occur during development when cells mature to differentiated cells as complex as neurons, and during malignant transformation.The goal of this STREP is to establish the connections between signalling pathways and membrane trafficking in the context of migrating, dividing and adhering mammalian cells.Through the study of membrane traffic in the course of cell differentiation, dedifferentiation, and during mitosis, we aim to unravel how important signalling pathways remodel the intracellular trafficking routes and conversely,how membrane traffic can influence signalling cascades.We will take advantage of several cellular models including neurons differentiating in culture and cancer cells dividing and migrating. We will investigate proteins that play central roles in membrane trafficking and secretion such as rabs,SNAREs and their partners. We will focus on the trafficking of signalling molecules including cell-cell and cell-substrate adhesion molecules, growth factors and their receptors, and also investigate the role of glycosylation. Through these approaches we will define the connections between Signalling and Traffic. Dziedzina nauki medical and health scienceshealth sciencespublic healthmedical and health sciencesbasic medicineneurologydementiaalzheimernatural sciencesbiological sciencescell biologycell signalingmedical and health sciencesclinical medicinephysiotherapymedical and health sciencesclinical medicineoncology Słowa kluczowe Cell Adhesion Cell Division Cell Migration Menbrane Trafficking Signalling Signalling : Menbrane Trafficking Program(-y) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) LIFESCIHEALTH-1.1 - Fundamental knowledge and basic tools for functional genomics in all organisms Zaproszenie do składania wniosków FP6-2002-LIFESCIHEALTH Zobacz inne projekty w ramach tego zaproszenia System finansowania STREP - Specific Targeted Research Project Koordynator INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE Wkład UE Brak danych Adres 101 rue de Tolbiac PARIS Francja Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (8) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko DEUTSCHES KREBSFORSCHUNGSZENTRUM Niemcy Wkład UE Brak danych Adres IM NEUENHEIMER FELD 280 10 19 49 HEIDELBERG Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych INSTITUT DE RECERCA DE L'HOSPITAL UNIVERSITARI VALL D'HEBRON' Hiszpania Wkład UE Brak danych Adres Psg. Ball d'Hebron 119-129' BARCELONA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA Portugalia Wkład UE Brak danych Adres Avenida da República, EAN Apart. 124 OEIRAS Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych FONDAZIONE ITALIANA PER LA RICERCA SUL CANCRO Włochy Wkład UE Brak danych Adres Via Corridoni 7 MILANO Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych INSTITUT CURIE, DIVISION DE RECHERCHE Francja Wkład UE Brak danych Adres 26, rue d'Ulm PARIS Zobacz na mapie Koszt całkowity Brak danych UNIVERSITÀ DI TORINO DIPARTIMENTO DI SCIENZE ONCOLOGICHE Włochy Wkład UE Brak danych Adres Via Verdi 8 TORINO Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych JOHANNES GUTENBERG-UNIVERSITÄT MAINZ Niemcy Wkład UE Brak danych Adres Bentzelweg 3 MAINZ Zobacz na mapie Koszt całkowity Brak danych INSERM-TRANSFERT SA Francja Wkład UE Brak danych Adres 101 Rue de tolbiac PARIS Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych