Objective Although there is abundant evidence for efficacy of antidepressants a substantial minority of patients show an unsatisfactory response, and cessation of medication because of adverse effects is common. The choice of what drug to prescribe for optimal response with minimum unwanted effects is largely a matter of taking an educated guess. Pharmacogenetics offers considerable potential to provide tools to aid targeted, rational prescribing. GENDEP has three closely interconnected major themes aimed to address these issues. The first is a large scale multi-centre clinical trial focussed on the prediction of therapeutic response to antidepressants and adverse effects. The second is a set of basic science studies using animal models and in vitro experiments, and the third is a programme of work to address the relevant ethical, social, and legal issues. This project will include an integrative analysis of the results of the transcriptomics and proteomics on the samples from the human, the rodent, and the in vitro studies, in order to identify biomarkers consistently identified across all of these experimental methodologies. This integrated project should lead to validated pharmacogenomic methods for symptom improvement, the prediction of response to psychiatric drug treatment and the reduction of adverse effects. We may also be able to make a beginning on identifying new targets for drug discovery.GENDEP will examine such associated issues as the views of service users regarding consent in human pharmacogenomics studies, a cost-benefit analysis of introducing pharmacogenomic theranostics, and the investigation of the potential impact of a new generation of pharmacogenomically tailored treatments on patients' and consumers' views and attitutdes. A key feature of the entire project is the active research involvement of stakeholders, including psychiatric service users, practising clinicians and industrial partners. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesclinical medicinepsychiatrymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugssocial sciencessociologyanthropologyscience and technology studies Keywords depressive disorder pharmacogenomics pharmacogenomics depressive disorder Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LIFESCIHEALTH-1 - Advanced genomics and its application for health LIFESCIHEALTH-1.2 - Application of knowledge and technologies in the field of genomics and biotechnology for health Call for proposal FP6-2002-LIFESCIHEALTH See other projects for this call Funding Scheme IP - Integrated Project Coordinator KING'S COLLEGE LONDON, INSTITUTE OF PSYCHIATRY EU contribution No data Address Strand London United Kingdom See on map Links Website Opens in new window Total cost No data Participants (18) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITY OF WALES COLLEGE OF MEDICINE United Kingdom EU contribution No data Address Cardigan house - heath park Cardiff (wales) See on map Links Website Opens in new window Total cost No data LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE United Kingdom EU contribution No data Address Houghton street London See on map Links Website Opens in new window Total cost No data THE PROVOST FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN, (HEREINAFTER TCD) Ireland EU contribution No data Address College green Dublin See on map Links Website Opens in new window Total cost No data UNIVERSITE LIBRE DE BRUXELLES, HOPITAL ERASME, DEPARTEMENT DE PSYCHIATRIE Belgium EU contribution No data Address 808 route de lennik Brussels See on map Links Website Opens in new window Total cost No data ZENTRALINSTITUT FUR SEELISCHE GESUNDHEIT Germany EU contribution No data Address J 5 122120 Mannheim See on map Links Website Opens in new window Total cost No data UNIVERSITATSKLINIKUM BONN, ANSTALT DES OFFENTLICHEN RECHTS, FUR DEN FACHBEREICH MEDIZIN DER UNIVERSITAT BONN Germany EU contribution No data Address Sigmund-freude-strasse 25 Bonn See on map Links Website Opens in new window Total cost No data KAROLINSKA INSTITUTE Sweden EU contribution No data Address Nanna svartzv.2 Stockholm See on map Links Website Opens in new window Total cost No data UNIVERSITA' DEGLI STUDI DI MILANO Italy EU contribution No data Address Via balzaretti 9 Milan See on map Links Website Opens in new window Total cost No data PROVINCIA LOMBARDO-VENETA-ORDINE OSPEDALIERO DI SAN GIOVANNI DE DIO-FATEBENEFRATELLI Italy EU contribution No data Address Via s. vittore, 12 Milano See on map Links Website Opens in new window Total cost No data AFDELING FOR PSYKIATRISK DEMOGRAFI, INSTITUT FOR PSYKIATRISK GRUNDFORSKNING Denmark EU contribution No data Address Skovagervej 2 Risskov See on map Links Website Opens in new window Total cost No data INSTITUT ZA VAROVANJE ZDRAVJA REPUBLIKE SLOVENIJE Slovenia EU contribution No data Address Trubarjeva 2 Pp 260 Ljubljana See on map Links Website Opens in new window Total cost No data HRVATSKI INSTITUT ZA ISTRAZIVANJE MOZGA, MEDICINSKI FAKULTET SVEDUCILISTA U ZAGREBU (CROATION INSTITUTE FOR BRAIN RESEARCH, MEDICAL SCHOOL, UNIVERSITY OF ZAGREB Croatia EU contribution No data Address Salata 12 Zagreb See on map Links Website Opens in new window Total cost No data PROTEOME SCIENCES PLC United Kingdom EU contribution No data Address Coveham house, downside bridge road Cobham See on map Links Website Opens in new window Total cost No data AKADEMIA MEDYCZNA IM. KAROLA MARCINKOWSKIEGO W POZNANIU Poland EU contribution No data Address Fredry 10 Poznan See on map Links Website Opens in new window Total cost No data GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD United Kingdom EU contribution No data Address 980 great west road Brentford, middlesex See on map Links Website Opens in new window Total cost No data GLAXOSMITHKLINE SPA Italy EU contribution No data Address Via fleming 2 Verona See on map Links Website Opens in new window Total cost No data GABO GESELLSCHAFT FUER ABLAUFORGANISATION, INFORMATIONSVERARBEITUNG UND KOMMUNIKATIONSORGANISATION GMBH & CO. KG Germany EU contribution No data Address Oskar-von-miller-ring 29 Muenchen See on map Total cost No data GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO Germany EU contribution No data Address Oskar-von-miller-ring 29 Muenchen See on map Total cost No data