Cel Decades of biomedical research in acute stroke has led to the discovery of genetic, molecular, neuroimaging and epidemiological disease markers that may profoundly improve the treatment of stroke patients - and the targeting and speedy testing of new therapies. The quantity and complexity of these data, however, currently prohibit the integration of this wealth of information into individualized patient management - and cost-effective drug development.I-Know is a knowledge discovery IT-based tool to aid early stroke diagnosis, stroke treatment, drug development and identification of risk factors as targets in disease prevention. In patient management, the I-Know system will use computerized stroke disease progression models (DPMs) (generated in this proposal) to provide an accurate diagnosis in individual patients (based on patient history and genetic profile, biochemical, clinical and neuroimaging findings). Interacting with the physician, I-Know will produce images, predicting the course of the disease given available therepeutic options and their specific actions recorded in other patients (DPMs from clinical trials). This allows physicians to diagnose and treat the patient on the basis of a wealth of information otherwise impossible to integrate by the human mind.In drug development, the pharmaceutical industry will use the I-Know stroke DPMs in classifying data in patients treated with new drug candidates, comparing it with DPMs from untreated patients. The statistical power of I-Know, we claim, far superceeds standard estimators of drug action (neurological outcome, infarct size), allowing demonstration of drug efficacy by a fraction of the patients, resources and time used today. The resulting, drug-specific DPM - accounting in unparalleled detail for drug action as well as adverse effects - is then supplied to the physician's I-Know system, allowing detailed prediction of a patient's individual response to the new drug. Dziedzina nauki medical and health sciencesbasic medicinepharmacology and pharmacydrug discoveryhumanitieshistory and archaeologyhistorymedical and health sciencesbasic medicineneurologystroke Program(-y) FP6-IST - Information Society Technologies: thematic priority under the specific programme "Integrating and strengthening the European research area" (2002-2006). Temat(-y) IST-2004-2.4.11 - Integrated biomedical information for better health Zaproszenie do składania wniosków Data not available System finansowania STREP - Specific Targeted Research Project Koordynator AARHUS UNIVERSITETSHOSPITAL, AARHUS SYGEHUS Wkład UE Brak danych Adres NOERREBROGADE 44 8000 AARHUS Dania Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (8) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko DIMAC A/S Dania Wkład UE Brak danych Adres MAGNOLIAVEJ 13 8260 VIBY Zobacz na mapie Koszt całkowity Brak danych FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO BIOMEDICA DE GIRONA DOCTOR JOSEP TRUETA Hiszpania Wkład UE Brak danych Adres AVENIDA DE FRANCIA S/N 17007 GIRONA Zobacz na mapie Koszt całkowity Brak danych INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francja Wkład UE Brak danych Adres RUE DE TOLBIAC 101 75654 PARIS CEDEX 13 Zobacz na mapie Koszt całkowity Brak danych SYSTEMATIC SOFTWARE ENGINEERING A/S Dania Wkład UE Brak danych Adres SOREN FRICHS VEJ 39 8000 ARHUS C Zobacz na mapie Koszt całkowity Brak danych THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Zjednoczone Królestwo Wkład UE Brak danych Adres The Old Schools, Trinity Lane CAMBRIDGE Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITAETSKLINIKUM FREIBURG Niemcy Wkład UE Brak danych Adres HUGSTETTER STRASSE 55 FREIBURG Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF Niemcy Wkład UE Brak danych Adres Martinistrasse 52 HAMBURG Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITE CLAUDE BERNARD LYON 1 Francja Wkład UE Brak danych Adres 43 BOULEVARD DU 11 NOVEMBRE 1918 69622 VILLEURBANNE Zobacz na mapie Koszt całkowity Brak danych