Pluripotency associated genes to de-differentiate neural cells into pluripotent cells

Projektinformationen

PLURIGENES

ID Finanzhilfevereinbarung: 18673

Startdatum 1 Januar 2006

Enddatum 31 Dezember 2009

Finanziert unter

• Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006.

Gesamtkosten € 3 716 458,00

EU-Beitrag € 2 499 713,00

Koordiniert durch

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
France

Ziel

A first step to regenerative medicine is to find a means to cause controlled de-differentiation of adult tissue. Plurigenes aims at achieving major breakthroughs in the discovery and understanding of the function of genes controlling pluripotency in the central nervous system. These later could enable the de-differentiation of terminally differentiated neural cells into pluripotent cells through transgenesis, a goal that fully meets the requirements of LSH-2004-1.1.0-1. Plurigenes will start by identifying candidate genes in model organisms, following original approaches involving screens performed by in situ hybridations on well characterised neural structures or by gain of function analysis. As pointed out in LSH-2004-1.1.0-1 innovative technologies of transgenesis and imaging in several model organisms will be settled to reach this goal. The project will first characterise in vitro and in vivo the functions of candidate genes involved in the maintenance of pluripotency. On selected genes, it will then validate the possibility to restore the pluripotency of terminally differentiated cells through transgenesis of the candidate genes. Finally, Plurigenes will identify molecular partners and related pathways associated with pluripotency. The project will result in the identification of evolutionarily conserved genes associated with cellular pluripotency; improved methods for transgenesis in fish and ascidians and innovative methods for cell imaging and finally, protocols for the de-differentiation of neural cells.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › neurobiology

Programm/Programme

• FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006.

Thema/Themen

• LSH-2003-1.1.0-1 - Topics for Specific Targeted Research Project in the area of Fundamental knowledge and basic tools for functional genomics in all organisms

Aufforderung zur Vorschlagseinreichung

FP6-2004-LIFESCIHEALTH-5
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

STREP - Specific Targeted Research Project

Koordinator

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

• EU-Beitrag: Keine Daten
• Adresse: 147, rue de l'Université ; PARIS ; Frankreich
• Gesamtkosten: Keine Daten

Beteiligte (7)

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Deutschland

• EU-Beitrag: Keine Daten
• Adresse: Meyerhofstraße 1 ; HEIDELBERG
• Gesamtkosten: Keine Daten

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Frankreich

• EU-Beitrag: Keine Daten
• Adresse: Rue Michel Ange, 3 ; PARIS
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STAZIONE ZOOLOGICA "ANTON DOHRN"

Italien

• EU-Beitrag: Keine Daten
• Adresse: Villa Comunale ; NAPOLI
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UNIVERSITY OF WUERZBURG

Deutschland

• EU-Beitrag: Keine Daten
• Adresse: Sanderring 2 ; WUERZBURG
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ONCODESIGN

Frankreich

• EU-Beitrag: Keine Daten
• Adresse: 20 rue Jean Mazen ; DIJON
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MEDICAL RESEARCH COUNCIL

Vereinigtes Königreich

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• Adresse: 20, Park Crescent ; LONDON
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UNIVERSITY OF MILANO BICOCCA

Italien

• EU-Beitrag: Keine Daten
• Adresse: Piazza dell'Ateneo Nuovo, 1' ; MILAN
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