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Role of Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation

Objectif

Our objective is to create the conditions for the rapid progress of research on the molecular principles of post-translational modifications of proteins by linkage of ubiquitin and ubiquitin-like molecules, the regulatory role of such modifications in basi c biological processes and their implications for pathological conditions that represent urgent socio-economic and human needs such as chronic inflammation, neurodegeneration and cancer. The RUBICON consortium will take a multi-disciplinary and multifacet ed approach to these problems. To enhance interdisciplinary research, RUBICON brings together investigators from different backgrounds that will work at all levels of a drug discovery oriented process. The organisation of the Joint Programme infrastructure s include shared RUBICON-funded core facilities and a web database serving as a European repository for biological research tools. Training will be provided by: a competitive programme of multi-centre postdoctoral fellowships, by mobility of scientists to RUBICON centres and platforms, and by open-lab meetings, summer schools and workshops. To feed back the benefits of integration into EU society, we have identified associated research groups and will open network meetings and fellowship programs to young investigators and scientists from new European countries. We aim to integrate research efforts within the first 18 months of the project, and then build on the infrastructure and collaborations established in order to enhance the competitiveness of Europea n research on ubiquitin and ubiquitin-like modifications, and promote, in concert with SMEs, the emergence of novel mechanism-based therapeutic approaches to diseases associated with disturbance of these basic regulatory processes.

Appel à propositions

FP6-2004-LIFESCIHEALTH-5
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Régime de financement

NoE - Network of Excellence

Coordinateur

KAROLINSKA INSTITUTET
Contribution de l’UE
Aucune donnée
Adresse
Nobels väg 5
STOCKHOLM
Suède

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Liens
Coût total
Aucune donnée

Participants (22)