Obiettivo A full and detailed understanding of the transmission cycles and epidemiology of visceral leishmaniasis (VL) and mucocutaneous leishmaniasis (MCL) is necessary to develop disease control and surveillance. Molecular epidemiology and population genetics can resolve the diversity and structure of Leishmania populations, for ex. the intricate relationships between clinical forms of human infection and mammal reservoirs. Research will involve comparative investigations between endemic areas for VL and MCL in Par aguay, Peru, Brazil and Venezuela and will strengthen local capacities for research and for Latin Am-European collaborations. The technical aim is to develop a full range of microsatellite markers and multi-locus sequencing typing (MLST) of housekeeping ge nes for the Leishmania braziliensis complex and for L guyanensis. We will also establish in South America the procedures for microsatellite and MLST analysis for L infantum, which have been developed and proven as epidemiological tools by a European networ k. The practical aims are to encourage the application of these and other molecular epidemiological methods in S. America for 1. elucidating parasite-vector-host relationships 2. assessing the epidemiological impact of VL-HIV co-infection (Brazil) 3. asses sing the epidemiological importance of recombinant Leishmania genotypes and 4. assessing the spread of resistance against 1st line treatment (SbV). In addition we will compare genotypes of a) Leishmania isolated from diverse clinical cases of leishmaniasis and b) drug susceptible and drug-resistant strains. The project will be undertaken in the context of an investigation of present understanding and intervention strategies among health professionals, defining how best to introduce project outputs into impr oved control. An accessible South American repository for Leishmania will be established, incorporating an existing collection, new isolates and representatives from other endemic regions. Campo scientifico natural sciencesbiological sciencesgeneticsmedical and health scienceshealth sciencespublic healthepidemiologynatural sciencesbiological scienceszoologymammalogy Programma(i) FP6-INCO - Specific measures in support of international cooperation: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) INCO - Specific measures in support of international co-operation INCO-2003-A1.3 b - Knowledge and technologies to improve control of neglected communicable diseases Invito a presentare proposte FP6-2003-INCO-DEV-2 Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE Contributo UE Nessun dato Indirizzo KEPPEL STREET LONDON Regno Unito Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (11) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE Germania Contributo UE Nessun dato Indirizzo Bernhard Nocht St 74 HAMBURG Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato CENTRO DE CIENCIAS DA SAUDE DA UNIVERSIDADE FEDERAL DO PIAUÍ Brasile Contributo UE Nessun dato Indirizzo Campus Petrônio Portela - bloco 16 - LIB TERESINA - PIAUÍ Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato CHARITE UNIVERSITAETSMEDIZIN BERLIN Germania Contributo UE Nessun dato Indirizzo Schumannstr. 20/21 BERLIN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato FUNDAÇÃO OSWALDO CRUZ - INSTITUTO OSWALDO CRUZ Brasile Contributo UE Nessun dato Indirizzo Avenida Presidente Vargas Brasil 590 Sala 1717 RIO DE JANEIRO Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD, UNIVERSIDAD NACIONAL DE ASUNCION Paraguay Contributo UE Nessun dato Indirizzo Rio de la Plata y Lagerenza ASUNCION Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato INSTITUTO DE SALUD CARLOS III Spagna Contributo UE Nessun dato Indirizzo Sinesio Delgado, 4 MADRID Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE Belgio Contributo UE Nessun dato Indirizzo Nationalestraat, 155 ANTWERPEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSIDAD DE CARABOBO - CENTRO DE INVESTIGACIONES BIOMÉDICAS-CENTRO NACIONAL DE REFERENCIA DE FLEBOTOMOS DE VENEZUELA Venezuela Contributo UE Nessun dato Indirizzo Callejón Cecilio Acosta, Urbanización Cantarrana, Sector la Rimconada, Las Delicias MARACAY Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSIDAD PERUANA CAYETANO HEREDIA/INSTITUTO DE MEDICINA TROPICAL "ALEXANDER VON HUMBOLDT" Perú Contributo UE Nessun dato Indirizzo Av. Honorio Delgado 430, San Martin de Porres LIMA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSIDADE FEDERAL DE MINAS GERAIS Brasile Contributo UE Nessun dato Indirizzo Av. Antonio Carlos 6627 BELO HORIZONTE-MG Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSIDADE NOVA DE LISBOA/INSTITUTO DE HIGIENE E MEDICINA TROPICAL Portogallo Contributo UE Nessun dato Indirizzo Rua da Junqueira, 96 LISBOA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato