Objectif There are over a million survivors of breast cancer in Europe today and this number is increasing rapidly due to increased incidence, improvements in treatment, and screening programmes. A recent overview of radiotherapy for early breast cancer showed that mortality from breast cancer was reduced in women given radiotherapy. This benefit was largely offset by the finding that women given radiotherapy experienced an increased risk of mortality from other causes, particularly cardiovascular disease. For breast cancer, improvements in radiotherapy techniques in recent years have reduced radiation doses to the heart. Many radiotherapy regimens still involve cardiac doses that may range up to a few Gy, and it seems likely that some cardiovascular risk remains with these regimens. There is thus an urgent need to obtain additional quantitative information on the size of the risk, so that it can be taken into account in the decision as to whether or not to treat a woman with radiotherapy and, if treatment is to be given, which radiotherapy regimen to use. Results from this study will provide information about the size of the cardiovascular risk from both past and present breast cancer radiotherapy regimens. This will be achieved by: (i) conducting large follow-up studies of women with breast cancer in Sweden and Denmark; (ii) developing methods to assess the radiation dose to the heart from different breast cancer radiotherapy regimens; (iii) conducting nested-case control studies within the two cohorts to establish a dose-response relationship for cardiac dose and cardiovascular risk. The information obtained about the risk of cardiovascular disease following low doses of radiation will also be of considerable practical use in other areas of radiological protection, and may be expected to contribute to the development of standards. Champ scientifique social sciencessociologydemographymortalitymedical and health sciencesclinical medicineoncologybreast cancermedical and health sciencesclinical medicinecardiologycardiovascular diseases Programme(s) FP6-EURATOM-RADPROT - Thematic priority - Radiation Protection as part of the specific framework programme for the European Atomic Energy Community, within the multi-annual framework programme 2002-2006. Thème(s) Data not available Appel à propositions EURATOMCALL2004-FIXEDDEADLINE Voir d’autres projets de cet appel Régime de financement STREP - Specific Targeted Research Project Coordinateur KAROLINSKA INSTITUTET Contribution de l’UE Aucune donnée Adresse Nobels vaeg 5 281 STOCKHOLM Suède Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (4) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire AALBORG SYGEHUS Danemark Contribution de l’UE Aucune donnée Adresse Hobrovej 18-22 AALBORG Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Royaume-Uni Contribution de l’UE Aucune donnée Adresse University Offices, Wellington Square OXFORD Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée OXFORD RADCLIFFE HOSPITALS NHS TRUST Royaume-Uni Contribution de l’UE Aucune donnée Adresse John Radcliffe Hospital - Headington - Headley Way OXFORD Voir sur la carte Coût total Aucune donnée SYDDANSK UNIVERSITET Danemark Contribution de l’UE Aucune donnée Adresse Campusvej, 55 ODENSE Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée