Objetivo Waste-free chemical processes are a must for a sustainable society. In nature, enzymes enable the atom economic synthesis of numerous natural products. Unfortunately, nature does not provide enzymes for the synthesis of the many pharmaceuticals, agrochemi cals and fine-chemicals that are needed. To solve this problem, our interdisciplinary scientific team wants to establish a paradigm shift in catalysis research by developing "artificial enzymes" containing transition metals that nature has not acquired for the production of important products.We propose a demanding new interdisciplinary approach for a 'de novo' design of metalloenzymes. Molecular recognition properties of proteins will be exploited by incorporation of metals such as rhodium, nickel and pall adium via amino acids containing phosphino ligands. Two types of artificial enzymes are targeted, namely those with mononuclear transition metals and those with transition metal nanoclusters that are stabilised by phosphine modified peptides, enabling effi cient cascade reactions. The design process is to be aided by molecular modeling and by structure determination using NMR and X-ray crystallography.By ligating small phosphino functionalised oligopeptides with proteins, we will create a new class of highly selective catalysts for reactions that nature can not perform, such as CO insertion, alkene insertion and (asymmetric) C-C coupling reactions. The catalytic performance and stability of these artizymes will be optimised by adjusting the amino acid sequenc e and the ligand structure. The protein part will induce the proper substrate orientation to the metal centre. Encapsulating substrates by these "synthetic proteins" will ultimately enable clean conversion of unfunctionalised molecules by C-H activation.Th ese catalysts will exhibit substrate specificity, i.e. they will be able to pick out a single substrate, even when it is present at low concentrations in complex mixtures. Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural scienceschemical sciencesinorganic chemistrytransition metalsnatural scienceschemical sciencescatalysisnatural scienceschemical sciencesorganic chemistryaminesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Palabras clave sustainability waste free production Programa(s) FP6-POLICIES - Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Tema(s) NEST-2003-1 - Adventure activities Convocatoria de propuestas FP6-2003-NEST-B-3 Consulte otros proyectos de esta convocatoria Régimen de financiación STREP - Specific Targeted Research Project Coordinador THE UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS Aportación de la UE Sin datos Dirección College Gate, North Street ST ANDREWS Reino Unido Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Participantes (6) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francia Aportación de la UE Sin datos Dirección Rue Michel-Ange, 3 PARIS Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos JUSTUS-LIEBIG-UNIVERSITAT GIESSEN Alemania Aportación de la UE Sin datos Dirección Ludwigstrasse 23 GIESSEN Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos UNIVERSIDADE DE SANTIAGO DE COMPOSTELA España Aportación de la UE Sin datos Dirección Pazo de San Xerome - Plaza do Obradoiro, s/n SANTIAGO DE COMPOSTELA Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos UNIVERSITEIT LEIDEN Países Bajos Aportación de la UE Sin datos Dirección Rapenburg 70 LEIDEN Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos UNIVERSITEIT VAN AMSTERDAM Países Bajos Aportación de la UE Sin datos Dirección Spui 21 AMSTERDAM Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG Países Bajos Aportación de la UE Sin datos Dirección De Boelelaan 1105 AMSTERDAM Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos